Protein Alignment D and Sox10

DIOPT Version :9

• Sequence 1: NP_001261830.1
• Gene: D / 39570
• FlyBaseID: FBgn0000411
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_062066.1
• Gene: Sox10 / 29361
• RGDID: 3735
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 452
• Identity: 115/452 - (25%)
• Similarity: 159/452 - (35%)
• Gaps: 175/452 - (38%)

  Fly    93 LSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSPGQ------------------- 138
            |||:    ||.|||...  |..||||.:|.|....|........|:
  Rat    23 LSPS----SAPSLGPDG--GGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLS 81

  Fly   139 -------------------EGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLA 184
                               :.|:||||||||||::..||::|...|.:||:|:||.||..|:||.
  Rat    82 GYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLN 146

  Fly   185 ESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNPLTAG---------PQGG------------ 228
            ||:|||||:||:|||..|.|:||||||:|||:.......|         .|||
  Rat   147 ESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGETDQGGAAAIQAHYKSAH 211

  Fly   229 -----------------------------------LQMQAGGMGQQKLGAGPGAGAGGYNPF--- 255
                                               .::|:|....::.|...|.|...:..|
  Rat   212 LDHRHPEEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNV 276

  Fly   256 ------HQ----------------LPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQS------- 291
                  |:                |||...|.|  ...|....:|....||::..|.:
  Rat   277 DIGEISHEVMSNMETFDVTELDQYLPPNGHPGH--VGSYSAAGYGLSSALAVASGHSAWISKPPG 339

  Fly   292 ---QAAAAAAVNNQGQQQGQAP-PQLPP-------------TSLS-SFYSGIYSGISAPSL---- 334
               ...:..||:.:.|.:.:.. ||.||             |||| ..|...:..||.|..
  Rat   340 VALPTVSPPAVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSD 404

  Fly   335 ------YAAHSANAAGLYPSSSTSSPG-------------SSPGTITPNGMDGSMDSALRRP 377
                  |..|:..|:|||.:.|...|.             |.|.:.:|...:..:.:.|.||
  Rat   405 HQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	44/70 (63%)
Sox10	NP_062066.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		17/49 (35%)
		Sox_N	12..93	CDD:289229	17/75 (23%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693	62..102		0/39 (0%)
		SOX-TCF_HMG-box	103..173	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..198		14/37 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..275		6/61 (10%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693	228..310		12/83 (14%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693	353..466		25/112 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..375		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..466		4/32 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810