DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and Sry

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_036904.1	Gene:	Sry / 25221	RGDID:	3759	Length:	169	Species:	Rattus norvegicus

Alignment Length:	187	Identity:	74/187 - (39%)
Similarity:	96/187 - (51%)	Gaps:	40/187 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 EGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHM 203
            |||:||||||||||||.:||::|:.||.|.||||||.||.:||.|.|:|||||..||:||:.||.
  Rat     2 EGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKHLGYQWKSLTEAEKRPFFQEAQRLKTLHR 66

  Fly   204 KEHPDYKYRPRRKPKNPLTAGPQGGLQMQAGG-----------------MGQQKLGAGPGAGAGG 251
            :::|:|||:|.|:.|.|..:..   ||.:...                 .||.      .|.|..
  Rat    67 EKYPNYKYQPHRRVKVPQRSYT---LQREVASTKLYNLLQWDNNLHTIIYGQD------WARAAH 122

  Fly   252 YNPFHQLPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQSQAAAAAAVNNQGQQQGQ 308
            .:..:|...|..|. .:..||         ||...:.||.|    ..|:.|.|||.|
  Rat   123 QSSKNQKSIYLQPV-DIPTGY---------PLQQKQQHQQQ----QHVHLQQQQQQQ 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	45/70 (64%)
Sry	NP_036904.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250\|UniProtKB:Q05066	4..81		48/76 (63%)
		SOX-TCF_HMG-box	4..74	CDD:238684	44/69 (64%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	6..22		13/15 (87%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250\|UniProtKB:Q05066	52..84		16/31 (52%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	75..81		2/5 (40%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000250\|UniProtKB:Q05738	92..144		9/67 (13%)
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000250\|UniProtKB:Q05738	94..138		7/50 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..169		10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910