DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and Meiosin

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001357740.1	Gene:	Meiosin / 243866	MGIID:	3647482	Length:	589	Species:	Mus musculus

Alignment Length:	208	Identity:	44/208 - (21%)
Similarity:	70/208 - (33%)	Gaps:	85/208 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SPNGPAGQGVNGSSGMGHHMSSHMTPHHMHQAVSAQQ---TLSPN----SSIGSAG--------- 103
            |..||.|                  |.:...:||...   :||.|    |:.||:.
Mouse   352 SSEGPTG------------------PPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLW 398

  Fly   104 ------------------SLGSQSSL-GSNGSGLNSSSGH----------QSAGM---------- 129
                              ||...|.| .:|..||.:||..          ||:|:
Mouse   399 GQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKV 463

  Fly   130 ----------HSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLA 184
                      .|....|||..  |:.:|.|:::.|:.|:|..:..|...::..:|.|...|:.:.
Mouse   464 QASQGPVKPKDSRKACPGQVK--KKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMT 526

  Fly   185 ESEKRPFIDEAKR 197
            ..||:|:..:|:|
Mouse   527 LEEKKPYCTKARR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	15/57 (26%)
Meiosin	NP_001357740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..27
		bHLH_SF	24..73	CDD:412148
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	28..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..191
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		5/28 (18%)
		NHP6B	416..>539	CDD:227935	30/124 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..457		10/34 (29%)
		HMG-box	484..539	CDD:238037	14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900