DRSC/TRiP Functional Genomics Resources

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Protein Alignment D and Sox8

DIOPT Version :9

Sequence 1:NP_001261830.1 Gene:D / 39570 FlyBaseID:FBgn0000411 Length:382 Species:Drosophila melanogaster
Sequence 2:NP_035577.1 Gene:Sox8 / 20681 MGIID:98370 Length:464 Species:Mus musculus


Alignment Length:337 Identity:101/337 - (29%)
Similarity:145/337 - (43%) Gaps:63/337 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HYSQSLAAMGGSPNGPAGQGVNGSSGMGH--HMSSHMTPHHMHQAVSAQQTLSPNSSIGSAGSLG 106
            |...|.:....||.|..|.|..|..|.|.  ..:....|..:..|||  |.|.     |...||.
Mouse    24 HVEDSDSDAPPSPAGSEGLGRAGGGGRGDTAEAADERFPACIRDAVS--QVLK-----GYDWSLV 81

  Fly   107 SQSSLGSNGSGLNSSSGHQSAGMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSE 171
            .....|..|..|.:                  :.|:||||||||||::..||::|...|.:||:|
Mouse    82 PMPVRGGGGGTLKA------------------KPHVKRPMNAFMVWAQAARRKLADQYPHLHNAE 128

  Fly   172 ISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNPLTAGPQGGLQMQAGGM 236
            :||.||..|:||:|||||||::||:|||..|.|:||||||:|||: |:..|    |.....:|  
Mouse   129 LSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRR-KSVKT----GRSDSDSG-- 186

  Fly   237 GQQKLGAGPGAGAGGYNPFHQLPPYFAPSHHLDQGYPVPYFGGFDPLALSK--LHQSQAAAAAAV 299
              .:||..||      .|.::.......:||....:.....|...|....|  |||:...:...:
Mouse   187 --TELGHHPG------GPMYKADAVLGEAHHHSDHHTGQTHGPPTPPTTPKTDLHQASNGSKQEL 243

  Fly   300 NNQGQQ---QGQAPPQLPPTSLSSFYSGIYSGISAPSLYA--------AHS--------ANAAGL 345
            ..:|::   .|:.........:|...|.:.|.:....::.        .||        |.|:|.
Mouse   244 RLEGRRLVDSGRQNIDFSNVDISELSSEVISNMDTFDVHEFDQYLPLNGHSALPTEPSQATASGS 308

  Fly   346 YPSSSTSSPGSS 357
            |..:|.|..|::
Mouse   309 YGGASYSHSGAT 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNP_001261830.1 SOX-TCF_HMG-box 141..212 CDD:238684 44/70 (63%)
Sox8NP_035577.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55 10/30 (33%)
Sox_N 18..86 CDD:315171 19/68 (28%)
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P57073 55..97 12/66 (18%)
SOX-TCF_HMG-box 98..168 CDD:238684 43/69 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..244 31/104 (30%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P57073 221..299 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..315 7/22 (32%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P57073 347..464
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..374
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..464
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.770

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