DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and Sox4

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_033264.2	Gene:	Sox4 / 20677	MGIID:	98366	Length:	440	Species:	Mus musculus

Alignment Length:	344	Identity:	114/344 - (33%)
Similarity:	158/344 - (45%)	Gaps:	79/344 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QQTLSPNSSIGSAGSLGSQSSLGSNGSGL-----NSSSGHQSAGMHSLATSPG----QEGHIKRP 145
            |||   |::..:...|..:||  .:|:||     :|.:...:|.....|..|.    ..||||||
Mouse     3 QQT---NNAENTEALLAGESS--DSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRP 62

  Fly   146 MNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYK 210
            ||||||||:::||:|.:.:|.|||:|||||||..||||.:|:|.|||.||:|||..||.::||||
Mouse    63 MNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYK 127

  Fly   211 YRPRRKPKNPLTAGPQGGLQMQAGGMGQQKLGAG-------PGAGAGGYN--------------- 253
            ||||:|.|:. .||.......:.|..|.:..|:.       .|.||||.:
Mouse   128 YRPRKKVKSG-NAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGSSKPAPKKSCGPKVAGS 191

  Fly   254 ----PFHQLPP--------YFAPSHHLDQGYPVPYFGGFDPLALSKLHQSQAAAAAAVNNQGQQQ 306
                |..:|.|        .|:|    :|...:| .|  :|.|:.|:....||..||  :.....
Mouse   192 SVGKPHAKLVPAGGSKAAASFSP----EQAALLP-LG--EPTAVYKVRTPSAATPAA--SSSPSS 247

  Fly   307 GQAPPQLPPT-----------SLSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPGSSPGT 360
            ..|.|...|.           ||.:..|.: .|:.|    :|..::..|||   ....||.||..
Mouse   248 ALATPAKHPADKKVKRVYLFGSLGASASPV-GGLGA----SADPSDPLGLY---EDGGPGCSPDG 304

  Fly   361 ITPNGMDGSMDS--ALRRP 377
            .:.:|...:..|  |.|.|
Mouse   305 RSLSGRSSAASSPAASRSP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	47/70 (67%)
Sox4	NP_033264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		14/59 (24%)
		SOX-TCF_HMG-box	58..129	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..211		19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..258		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..382		16/60 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910