DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and Sox11

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_033260.4	Gene:	Sox11 / 20666	MGIID:	98359	Length:	395	Species:	Mus musculus

Alignment Length:	324	Identity:	105/324 - (32%)
Similarity:	141/324 - (43%)	Gaps:	106/324 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 GHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMK 204
            ||||||||||||||:::||:|.:.:|.|||:|||||||..||:|.:|||.|||.||:|||..||.
Mouse    47 GHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMA 111

  Fly   205 EHPDYKYRPRRKPKNPLTAGPQGGLQ--------MQAGGMGQQ---------KLGAG----PGAG 248
            ::||||||||:|||....|.|..|..        ..|.|.|::         |.|||    ||..
Mouse   112 DYPDYKYRPRKKPKTDPAAKPSAGQSPDKSAAGAKAAKGPGKKCAKLKAPAGKAGAGKAAQPGDC 176

  Fly   249 AGGY---------------------------------NPFHQ--LPPYFAPSHHLDQGYPVPYFG 278
            |.|.                                 .|.|.  |||   |:    |..|.....
Mouse   177 AAGKAAKCVFLDDDDEDDDEDDELQLRPKPDADDDDDEPAHSHLLPP---PT----QQQPPQLLR 234

  Fly   279 GFDPLALSKLHQSQAAAAAAVNNQG----------------------QQQGQAPPQLPPTS---- 317
            .:   :::|:..|...::||.:.:|                      ||...|||.|.|.|
Mouse   235 RY---SVAKVPASPTLSSAAESPEGASLYDEVRAGGRLYYSFKNITKQQPPPAPPALSPASSRCV 296

  Fly   318 LSSFYSGIYSGISAP---------SLYAAHSANAAGLYPSSSTSSPGSSPGTITPNGMDGSMDS 372
            .:|..||..||..|.         ||..:..|::|...|..:     .:.|.::.:.:|..:||
Mouse   297 STSSSSGSSSGSGAEDADDLMFDLSLNFSQGAHSACEQPLGA-----GAAGNLSLSLVDKDLDS 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	47/70 (67%)
Sox11	NP_033260.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SOX-TCF_HMG-box	48..119	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..258		38/153 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..312		14/35 (40%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269\|PubMed:18403418	363..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910