Protein Alignment D and sem-2

DIOPT Version :9

• Sequence 1: NP_001261830.1
• Gene: D / 39570
• FlyBaseID: FBgn0000411
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_740846.1
• Gene: sem-2 / 172162
• WormBaseID: WBGene00004771
• Length: 404
• Species: Caenorhabditis elegans
• Alignment Length: 390
• Identity: 114/390 - (29%)
• Similarity: 152/390 - (38%)
• Gaps: 129/390 - (33%)

  Fly    74 MSSHMTPHHMHQAVSAQQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSPG- 137
            |.....|:.|.....|...:.|.:...:|.::.|.:|..:|.:..||.:..|....|...|:.|
 Worm     1 MDLQKPPNFMLDCGMAPHMMPPINWAAAAIAVASSTSGATNATSSNSVATSQQLQHHPYGTAAGG 65

  Fly   138 -----------------------QEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAE 179
                                   ...|||||||||||||:::||:|.:..|.|||:||||:||:.
 Worm    66 YKHAQQAIPKSVTPYSDATNCKKSSNHIKRPMNAFMVWSQMERRKICEHQPDMHNAEISKQLGSR 130

  Fly   180 WKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNPLTAGPQGGLQMQAGGMGQQK---- 240
            |:.|.:.||.||:.||:|||..||:|:|||||:||:|||.    .|.|.||..|.....|:
 Worm   131 WRSLTDEEKAPFVAEAERLRVCHMQEYPDYKYKPRKKPKK----NPDGTLQQPAQPQAPQQQQAP 191

  Fly   241 -LGAGPGA----------------------------GAGGYNPFHQLPPYFAPSHHLDQGYPVPY 276
             .||.|.|                            ..|..:..|.....|.||      ||.|.
 Worm   192 PRGASPQARQRKRPNTDQQSETQQFQNFKSVKVEQDWMGNAHMSHAQKMPFHPS------YPSPS 250

  Fly   277 FGGFDPLA------------------LSKLHQSQAAAAAAVNNQGQQQGQAPPQL---------- 313
            ..|..||.                  .:..|.:.|.:...:.|.|...|. |||:
 Worm   251 EFGHAPLTPESGFYDDYFTQQHHQQHFASQHHNSAGSPLRMTNLGMDMGM-PPQMMGHNSGFGAG 314

  Fly   314 ---------PPT-------SLSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPGSSPGTIT 362
                     ||:       ||||..||          ||..||:      ..|||||.|: |.:|
 Worm   315 NHPFYLHTSPPSVDQDDMRSLSSGSSG----------YADCSAS------EQSTSSPNSA-GVVT 362

  Fly   363  362
             Worm   363  362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	44/70 (63%)
sem-2	NP_740846.1	SOX-TCF_HMG-box	92..159	CDD:238684	40/66 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.890