DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and Sox9

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_536328.1	Gene:	Sox9 / 140586	RGDID:	620474	Length:	507	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	131/553 - (23%)
Similarity:	175/553 - (31%)	Gaps:	250/553 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QAQGLEDYAPQSQLQLSPGMDMDIKRVLHYSQSLAAMGGSPNGPAGQGVN-------------GS 67
            |.:||.. ||      ||.|..|             ..||| .|:|.|.:             |.
  Rat    14 QEKGLSG-AP------SPTMSED-------------SAGSP-CPSGSGSDTENTRPQENTFPKGE 57

  Fly    68 SGMGHHMSSHMTPHHMHQAVSA-----QQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSA 127
            ..:.........|..:.:|||.     ..||.|             ..:..|||..|
  Rat    58 PDLKKESEEDKFPVCIREAVSQVLKGYDWTLVP-------------MPVRVNGSSKN-------- 101

  Fly   128 GMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFI 192
                       :.|:||||||||||::..||::|...|.:||:|:||.||..|:||.|||||||:
  Rat   102 -----------KPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFV 155

  Fly   193 DEAKRLRALHMKEHPDYKYRPRRK----------------------------------------- 216
            :||:|||..|.|:||||||:|||:
  Rat   156 EEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSE 220

  Fly   217 -------------PKNPLTAGPQGGLQMQAGGMGQQKLGAGPGAGAGGYNPF------------- 255
                         |..|.|. |:  ..:|||.:..::.|. |.|..|...|.
  Rat   221 VHSPGEHSGQSQGPPTPPTT-PK--TDVQAGKVDLKREGR-PLAEGGRQPPIDFRDVDIGELSSD 281

  Fly   256 ----------HQLPPYFAPSHHLDQGYP-----VPYFGGF-------DPLALSKLHQSQAAAAAA 298
                      ::...|..|:.|  .|.|     |.|.|.:       .|.....:..|:..|...
  Rat   282 VISNIETFDVNEFDQYLPPNGH--PGVPATHGQVSYTGSYGISSTAPTPATAGHVWMSKQQAPPP 344

  Fly   299 VNN---QGQQQGQAPP--QLPP--------------TSLS------------------SFYSG-- 324
            ...   |..|..||||  |.||              |:||                  |.||.
  Rat   345 PPQQPPQAPQAPQAPPQQQAPPQPQQAPQQQQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQ 409

  Fly   325 -------IYSGISAP-----------------------SLYAAHSANAAGLY------------- 346
                   .||..:.|                       |.|:..:...:|||
  Rat   410 QHSPQQISYSPFNLPHYNPSYPTITRSQYDYTDHQNSGSYYSHAAGQGSGLYSTFTYMNPAQRPM 474

  Fly   347 --PSSSTSSPGSSPGTITPNGMDGSMDSALRRP 377
              |.:.||...|.|.|.:|...:..:.:.|.||
  Rat   475 YTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	44/70 (63%)
Sox9	NP_536328.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		16/73 (22%)
		Sox_N	22..94	CDD:403592	19/104 (18%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		11/71 (15%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		11/71 (15%)
		SOX-TCF_HMG-box	104..174	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..271		26/114 (23%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..307		16/88 (18%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	275..284		0/8 (0%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..429		20/93 (22%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	392..507		19/114 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507		8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810