DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and sox8a

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001271361.1	Gene:	sox8a / 102216265	ZFINID:	ZDB-GENE-130530-719	Length:	401	Species:	Danio rerio

Alignment Length:	349	Identity:	103/349 - (29%)
Similarity:	139/349 - (39%)	Gaps:	122/349 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 GMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFI 192
            |..||...|    |:||||||||||::..||::|...|.:||:|:||.||..|:||:|||||||:
Zfish    76 GSRSLKDKP----HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFV 136

  Fly   193 DEAKRLRALHMKEHPDYKYRPRR----KP-KNPLTAGPQGGL-------QMQAG--GMGQQKLGA 243
            :||:|||..|.|::|||||:|||    || :|...||.:..|       :.:||  .|..|.:
Zfish   137 EEAERLRLQHKKDYPDYKYQPRRRKSLKPGQNEAEAGAEKNLHHTDPIYKTEAGMRAMHHQTI-- 199

  Fly   244 GPGAGAGGYNPFHQLPPYFAPSHHLDQG--------------------------------YPVPY 276
                  .|..|.....|...|.....|.                                :.|..
Zfish   200 ------HGVQPHGPPTPPTTPKSDQHQSMKRLSENARQNIDFSNVDISELSSDVIGSISQFDVRE 258

  Fly   277 FGGFDPL-----------------ALSKLHQSQAAA---------AAAVNNQ------------- 302
            |..:.||                 :.|..|.|.|:|         .::.|.|
Zfish   259 FDQYLPLNGHTESGGGQHSSPGCFSTSFHHHSGASAWNKPSGSPSTSSANQQRPLIKTEQLSPSH 323

  Fly   303 -GQQQGQ---------APPQLPP--TSLSSFYSGIYSGISAPSLYA-AHSANAAGLYPSSST-SS 353
             ||..|.         |..|..|  |:.|.:.:|||.       |. .||...:.:.|..:| ||
Zfish   324 YGQSHGSPTQSELSDCADMQNSPYFTTFSGYPAGIYQ-------YPYFHSTRRSYMTPVLNTLSS 381

  Fly   354 PGSSPGTITPNGMDGSMDSALRRP 377
            |..||||    ..:..:.:.|.||
Zfish   382 PSHSPGT----NWEQPVYTTLTRP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	43/70 (61%)
sox8a	NP_001271361.1	Sox_N	<40..73	CDD:372113
sox8a	NP_001271361.1	SOX-TCF_HMG-box	85..155	CDD:238684	42/69 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910