DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and sox10

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001093691.1	Gene:	sox10 / 100101700	XenbaseID:	XB-GENE-480304	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	323	Identity:	100/323 - (30%)
Similarity:	133/323 - (41%)	Gaps:	111/323 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 HIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKE 205
            |:||||||||||::..||::|...|.:||:|:||.||..|:||.|::|||||:||:|||..|.|:
Frog    89 HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKD 153

  Fly   206 HPDYKYRPRR----KP----------------------KN---------PL-------TAGPQGG 228
            ||||||:|||    ||                      ||         |:       :||...|
Frog   154 HPDYKYQPRRRKNGKPNPGEGDGSSEAEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSAGQSHG 218

  Fly   229 ---------LQMQAGGM-----GQQKLGAG--PGAGAGG------------------YNPFHQLP 259
                     .::|||..     |.:.||.|  |....|.                  .|.|.|
Frog   219 PPTPPTTPKTELQAGKSDGKRDGSRSLGEGGKPHIDFGNVDIGEISHDVMANMETFDVNEFDQ-- 281

  Fly   260 PYFAPSHHLDQGYPVPYFGGF--------------DPLALSKLH-QSQAAAAAAVNNQGQQQGQA 309
             |..|:.|  .|:| .:.||:              ...||:|.| |:.:.|.....:........
Frog   282 -YLPPNGH--AGHP-SHIGGYTSSYGLSGALAAGPSAWALAKQHPQTDSKAQVKTESSSTSHYTE 342

  Fly   310 PP---QLPPTSLS-SFYSGIYSGISAP----------SLYAAHSANAAGLYPSSSTSSPGSSP 358
            .|   ||..|||. ..|...:..||.|          |.|.:||:.|:.||.:.|...|...|
Frog   343 QPSTSQLTYTSLGLPHYGSAFPSISRPQFDYADHQPSSSYYSHSSQASSLYSAFSYMGPPQRP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	43/70 (61%)
sox10	NP_001093691.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Sox_N	12..79	CDD:372113
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	48..88
		SOX-TCF_HMG-box	89..159	CDD:238684	42/69 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		16/37 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..257		12/61 (20%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	209..295		20/91 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..346		3/23 (13%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	327..436		21/79 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910