DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and Sox11

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_445801.1	Gene:	Sox11 / 84046	RGDID:	69351	Length:	395	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	101/334 - (30%)
Similarity:	144/334 - (43%)	Gaps:	74/334 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 HIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKE 311
            |||||||||||||:::||||.:.:|.|||:|||||||..||:|.:.||.|||.||:|||..||.:
  Rat    48 HIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMAD 112

  Fly   312 HPDYKYRPRRKPKALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAA-------------AY 363
            :||||||||:|||.       .|...||       ||.:|...|.|..||             |.
  Rat   113 YPDYKYRPRKKPKT-------DPAAKPS-------AGQSPDKSAAGAKAAKGPGKKCAKLKAPAG 163

  Fly   364 HLGSHLGQTSTPTTTQATLSGQM-------------DKFALERSSYLSNSSQASAYSAYLDPSV- 414
            ..|:  |:.:.|....|..:.:.             |:..|.......:.....|:|..|.|..
  Rat   164 KAGA--GKAAQPGDCGAGKAAKCVFLDDDDEEDDEDDELQLRPKPDADDDDDEPAHSHLLPPPAQ 226

  Fly   415 -----LTKAYFDSKMYQDRAANYAFDI---SKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSG 471
                 |.:.|..:|:......:.|.:.   :.:|...:.....:...:...:||.......|  .
  Rat   227 QQPPQLLRRYSVAKVPASPTLSSAAESPEGASLYDEVRAGGRLYYSFKNITKQQPPPAPPAL--S 289

  Fly   472 GGGSGGGGSASSHNNNSSSGLDDRDATPQLEAVESKPHLHSPSDVGLDYAQYAQQYGGQLAAAAG 536
            ...|....::||..::|.||.:|.|              ....|:.|:::|.|.       :|..
  Rat   290 PASSRCVSTSSSSGSSSGSGAEDAD--------------DLMFDLSLNFSQGAH-------SACE 333

  Fly   537 GAVGGGAAG 545
            ..:|.||||
  Rat   334 QPLGAGAAG 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	47/70 (67%)
Sox11	NP_445801.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SOX-TCF_HMG-box	48..119	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..258		36/159 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..312		9/37 (24%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q7M6Y2	363..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910