DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and SOX10

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_008872.1	Gene:	SOX10 / 6663	HGNCID:	11190	Length:	466	Species:	Homo sapiens

Alignment Length:	521	Identity:	129/521 - (24%)
Similarity:	194/521 - (37%)	Gaps:	161/521 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SQSQALSHQTHSNGSSQ----LGGGSASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLHHNSQA 207
            ::.|.||....|...|:    |..|||...|...||..:...::|....:   ........:.:|
Human     2 AEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGEL---GKVKKEQQDGEA 63

  Fly   208 S----PISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQ 268
            .    |:. :.:.:..:: ||...:.|...:.:...:|  ::.|:||||||||||::..|||:|.
Human    64 DDDKFPVC-IREAVSQVL-SGYDWTLVPMPVRVNGASK--SKPHVKRPMNAFMVWAQAARRKLAD 124

  Fly   269 DNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKALRRDGYPY 333
            ..|.:||:|:||.||..|:||.|.:|||||:||:|||..|.|:||||||:|||:.......|
Human   125 QYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQG--- 186

  Fly   334 PMPYPSVPVEALRAGITPGYFAPGPTAA--AYHLGSHL------------------------GQT 372
                     ||...|   |....|.|||  |::..:||                        |..
Human   187 ---------EAECPG---GEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPP 239

  Fly   373 STPTTTQATL-SGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDI 436
            :.|||.:..| ||:.|.   :|    ...|.......::|        |.:           .||
Human   240 TPPTTPKTELQSGKADP---KR----DGRSMGEGGKPHID--------FGN-----------VDI 278

  Fly   437 SKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSG---------GGGSGGGGS---ASSHN---- 485
            .:|        :|......:.....:..|.|..:|         ..|.|.|.:   ||.|:
Human   279 GEI--------SHEVMSNMETFDVAELDQYLPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWIS 335

  Fly   486 --------NNSSSGLD-------------------DRDATPQLEAVE-SKPHLHSP----SDVGL 518
                    ..|..|:|                   |:.:|.|:.... |.||..|.    |....
Human   336 KPPGVALPTVSPPGVDAKAQVKTETAGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQF 400

  Fly   519 DYAQYAQQYGGQLAAAAGGAVGGGAAGAAGGSAGGGSGGATAADF----RRPLTVIFXPPSSNGS 579
            ||:.:.                  .:|...|.:|..||..:|..:    :|||.... .||.:|.
Human   401 DYSDHQ------------------PSGPYYGHSGQASGLYSAFSYMGPSQRPLYTAISDPSPSGP 447

  Fly   580 E 580
            :
Human   448 Q 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	44/70 (63%)
SOX10	NP_008872.1	Sox_N	12..93	CDD:315171	15/85 (18%)
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	62..102		6/43 (14%)
		SOX-TCF_HMG-box	103..173	CDD:238684	43/69 (62%)
		Nuclear export signal	134..145		5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..199		18/53 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..274		12/76 (16%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	228..310		19/115 (17%)
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	353..466		22/114 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..375		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		14/67 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810