Protein Alignment Sox21b and SOX9

DIOPT Version :10

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_000337.1
• Gene: SOX9 / 6662
• HGNCID: 11204
• Length: 509
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 109/386 - (28%)
• Similarity: 156/386 - (40%)
• Gaps: 112/386 - (29%)

  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :|:.|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.|||||::||:|||..
Human   100 KNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQ 164

  Fly   308 HMKEHPDYKYRPRRKP------------------------KALRRDGYPYPMPYPSVPVEALRAG 348
            |.|:||||||:|||:.                        |||:.|.     |:.|       :|
Human   165 HKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADS-----PHSS-------SG 217

  Fly   349 ITPGYFAPGPTAAAYHLGSHLGQTSTPTTTQATLSGQMDKFALER-------------------- 393
            ::..: :||.     |.|...|..:.|||.:..:  |..|..|:|
Human   218 MSEVH-SPGE-----HSGQSQGPPTPPTTPKTDV--QPGKADLKREGRPLPEGGRQPPIDFRDVD 274

  Fly   394 -----SSYLSN--SSQASAYSAYLDPS----------VLTKAYFDSKMYQDRAANYAFDISKIYG 441
                 |..:||  :...:.:..||.|:          .:|  |..|......||..| ....::.
Human   275 IGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVT--YTGSYGISSTAATPA-SAGHVWM 336

  Fly   442 AQQHAAAHHQQQQQQ----------------QQ-----QQQQQQQQLLLSGGGGSGGGGSASSHN 485
            ::|.|.....||..|                ||     ||.|......||...|........:..
Human   337 SKQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQ 401

  Fly   486 NNSSSGLDDRDATPQLEAVE--SKPHLHSPSDVGLDYAQY----AQQYGGQLAAAAGGAVG 540
            .:.|...:.:..:||..|..  :.|| :|||...:..:||    .|......:.|||...|
Human   402 LSPSHYSEQQQHSPQQIAYSPFNLPH-YSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTG 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	48/102 (47%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67
		Sox_N	22..94	CDD:463586
		Dimerization (DIM). /evidence=ECO:0000305|PubMed:31194875	63..103		1/2 (50%)
		PQA. /evidence=ECO:0000305|PubMed:31194875	63..103		1/2 (50%)
		HMG-box_SoxE	104..178	CDD:438840	46/73 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..273		33/132 (25%)
		Transactivation domain (TAM). /evidence=ECO:0000269|PubMed:31194875	224..307		18/89 (20%)
		9aaTAD 1. /evidence=ECO:0000269|PubMed:31194875	275..284		1/8 (13%)
		9aaTAD 2. /evidence=ECO:0000269|PubMed:31194875	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..415		14/84 (17%)
		Transactivation domain (TAC). /evidence=ECO:0000269|PubMed:8640233	394..509		16/69 (23%)
		9aaTAD 3. /evidence=ECO:0000269|PubMed:34342803	460..468		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	479..509