Protein Alignment Sox21b and SOX5

DIOPT Version :10

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_011519134.2
• Gene: SOX5 / 6660
• HGNCID: 11201
• Length: 828
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 101/378 - (26%)
• Similarity: 139/378 - (36%)
• Gaps: 132/378 - (34%)

  Fly    96 GSPNGSTGLGLHPHSALHLAHHHSQLHQHHPAGQQQQHSQP------PVSS------SSTSHHSQ 148
            |.|.|:.|..:.|.|.     |..:.....|...:.:.:||      |.:|      |.||.|..
Human   424 GIPQGNLGAAVSPTSI-----HTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMP 483

  Fly   149 SQALSHQTHSNGSSQLGGGSASGAGSVAGGAANSHHSAPASSSVMAAAAA--------AHLH-HN 204
            :..::                ||||             |..:||.||.|:        .:|: |:
Human   484 ALRIN----------------SGAG-------------PLKASVPAALASPSARVSTIGYLNDHD 519

  Fly   205 SQASPISNLHQ-------------------NMGSLMNSGSSASDVFFSLMIQNTTKRQNEE---- 246
            :....|....|                   |...|.|..:.........:.|....:||||
Human   520 AVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFS 584

  Fly   247 -----------------------------------HIKRPMNAFMVWSRLQRRKIAQDNPKMHNS 276
                                               ||||||||||||::.:||||.|..|.||||
Human   585 HAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNS 649

  Fly   277 EISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKP--------------KALR 327
            .|||.||:.||.:|..||:|:.:|..||...|::::|||||:||.|.              ||:.
Human   650 NISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIM 714

  Fly   328 RDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAAA----YHLGS-HLGQTSTP 375
            |:.......|.:|..:|.....|.|...||..|.|    .||.| |...:|:|
Human   715 RNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSP 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	46/131 (35%)
SOX5	XP_011519134.2	HMG-box_EGL13-like	619..696	CDD:438848	44/76 (58%)