Protein Alignment Sox21b and SOX17

DIOPT Version :9

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_071899.1
• Gene: SOX17 / 64321
• HGNCID: 18122
• Length: 414
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 112/433 - (25%)
• Similarity: 163/433 - (37%)
• Gaps: 135/433 - (31%)

  Fly   168 SASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFF 232
            |:..||..:...:.:..:.||   |||.........:  .|||.::.....:..|||:.|.
Human     2 SSPDAGYASDDQSQTQSALPA---VMAGLGPCPWAES--LSPIGDMKVKGEAPANSGAPAG---- 57

  Fly   233 SLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPF 297
                 ...:.:.|..|:|||||||||::.:|:::||.||.:||:|:||.||..||.||..|||||
Human    58 -----AAGRAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPF 117

  Fly   298 IDEAKRLRAMHMKEHPDYKYRPRRKP--KALRR--DGYPYPMPYPS----------VPVEALRAG 348
            ::||:|||..||::||:|||||||:.  |.|:|  .|:.:.:..|.          |.::.|...
Human   118 VEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLGLQ 182

  Fly   349 ITPGYFAPGPTAAAYHLGSH-----------LGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQ 402
            .....|..||.....|:|.|           |.....||...:.|.|
Human   183 FPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPLPTPDTSPLDG------------------ 229

  Fly   403 ASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDISKI---------------------------- 439
                   :||.   .|:|.:.|..|..|...:..:::
Human   230 -------VDPD---PAFFAAPMPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIP 284

  Fly   440 ------------YGAQQHAAA----HHQQQQQQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNNS 488
                        |||.....|    ..|.|.|.|.|.|.|..         ..|.|..|.    .
Human   285 GLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQHQHQHQHQHH---------PPGPGQPSP----P 336

  Fly   489 SSGLDDRDATP---------QLEAVESKPHLH--SPSDVGLDY 520
            ...|..||.|.         :::..|.:.:||  ...::||.|
Human   337 PEALPCRDGTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPY 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	42/70 (60%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..66		7/38 (18%)
		SOX-TCF_HMG-box	67..138	CDD:238684	42/70 (60%)
		Sox_C_TAD	201..412	CDD:288887	37/220 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		0/29 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..352		15/59 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940