DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox14

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001032769.1	Gene:	sox14 / 557661	ZFINID:	ZDB-GENE-051113-268	Length:	238	Species:	Danio rerio

Alignment Length:	220	Identity:	102/220 - (46%)
Similarity:	125/220 - (56%)	Gaps:	53/220 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 EHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMK 310
            :||||||||||||||.||||:||:||||||||||||||||||||:|.||||:|||||||||.|||
Zfish     6 DHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMK 70

  Fly   311 EHPDYKYRPRRKPK-ALRRDGYPYPMPY-------PSVPVEA----LRAGITPGYFAPGPTAAAY 363
            |||||||||||||| .|::|.|.:|:||       ..:||.|    |.:......|.| ||:|.|
Zfish    71 EHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDHLKGLPVSATDSLLGSSEKARAFLP-PTSAPY 134

  Fly   364 HLGSHLGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDR 428
               |.|..:            |....|:::.:.:.::...|           |..|..|..||:.
Zfish   135 ---SFLDPS------------QFSSSAIQKMTEMPHTLATS-----------TLPYASSLGYQNG 173

  Fly   429 AANYAFDISKIYGA----QQHAAAH 449
            |          :|:    .||...|
Zfish   174 A----------FGSLGCPSQHTHTH 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	63/70 (90%)
sox14	NP_001032769.1	SOX-TCF_HMG-box	7..78	CDD:238684	63/70 (90%)
sox14	NP_001032769.1	SOXp	77..>95	CDD:289133	11/17 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm26545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.900