Protein Alignment Sox21b and SOX6

DIOPT Version :9

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001139291.2
• Gene: SOX6 / 55553
• HGNCID: 16421
• Length: 828
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 124/606 - (20%)
• Similarity: 193/606 - (31%)
• Gaps: 209/606 - (34%)

  Fly    14 LSLAHPLQTHLGSGGGTHHLGQLAAAVHQQQQQQQQSDQGLGHSHHLHGQQLSLNHQHH------ 72
            |..||..|..|.:........|:..|..||:|..:|..|.|...|.::..|..:..|.|
Human   205 LLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMI 269

  Fly    73 --HPHQ---------------------------------------------SP-QHQQQHQHHPC 89
              .||.                                             || |.|:.|..||.
Human   270 PIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQ 334

  Fly    90 SSNSSNG-SPNGSTGLGLHPHSALHLAHHHSQLHQHH----------PAGQQQQHSQPPVSSSST 143
            .:....| |......|....|...| :::|.|:.|.:          |..:.....|||.::.:.
Human   335 INQRLKGLSDRFGRNLDTFEHGGGH-SYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTV 398

  Fly   144 S-------------------------------------------------HHSQSQALSHQTHSN 159
            |                                                 ..|::..::....|:
Human   399 SPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSS 463

  Fly   160 GSSQLGGGSASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLHH---------------NSQASP 209
            ..|.:||....|:......:.||........:||.|...|....               :.:.|.
Human   464 IPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSS 528

  Fly   210 ISNL-------------HQNMG-----------------------------SLMNSGSSASDVFF 232
            |:|:             .:|:|                             ..||..::....::
Human   529 INNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYY 593

  Fly   233 SLMIQNTT------------KRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAE 285
            .......|            :..:|.||||||||||||::.:||||.|..|.||||.|||.||:.
Human   594 CWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSR 658

  Fly   286 WKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRK------PKALRRDGYPYPM--------- 335
            ||.::.:||:|:.:|..||..:|::::|:|||:||.|      .|.||...|...|
Human   659 WKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQ 723

  Fly   336 -----PYPSVPVEALRAGITPGYFAPGPTAAAYHLGSHLGQTST---PT--TTQATLSGQMDKFA 390
                 ..|.:|:......:.||......|..:..:.|....||.   |:  ..|:|...:.|..:
Human   724 FFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGS 788

  Fly   391 LERSSYLSNSSQASAYSAYLD 411
            |..:..::...:...|..|.|
Human   789 LAGNEMINGEDEMEMYDDYED 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	39/70 (56%)
SOX6	NP_001139291.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..470		8/89 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..828		11/57 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810