DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox21b and sox9

DIOPT Version :9

Sequence 1:NP_001261829.1 Gene:Sox21b / 39569 FlyBaseID:FBgn0042630 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001016853.1 Gene:sox9 / 549607 XenbaseID:XB-GENE-1034769 Length:482 Species:Xenopus tropicalis


Alignment Length:323 Identity:103/323 - (31%)
Similarity:148/323 - (45%) Gaps:60/323 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :::.|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.|||||::||:|||..
 Frog   100 KSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRIQ 164

  Fly   308 HMKEHPDYKYRPRRKP-----KALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAAA----- 362
            |.|:||||||:|||:.     ::.:.||.......|:...:||:        |..|.:|:     
 Frog   165 HKKDHPDYKYQPRRRKSVKNGQSEQEDGAEQTHISPNAIFKALQ--------ADSPHSASSMSEV 221

  Fly   363 YHLGSHLGQTS---TPTTTQATLSGQMDKFALERSSY-LSNSSQASAYSAYLDPS--------VL 415
            :..|.|.||:.   ||.||..| ..|..|..|:|... |..|.:...:..:.|..        :.
 Frog   222 HSPGEHSGQSQGPPTPPTTPKT-DVQPGKPDLKREGRPLQESGRQPPHIDFRDVDIGELSSEVIS 285

  Fly   416 TKAYFDSKMYQ------------DRAANY--AFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQ 466
            |...||...:.            ...|.|  ::.|:....|...|......:||||||||.|..|
 Frog   286 TIETFDVNEFDQYLPPNGHPGVGSTQAPYTGSYGINSTPSATPGAGPAWMSKQQQQQQQQPQPPQ 350

  Fly   467 LLLSGGGGSGGGGSASSHNNNSSSGLDDRDATPQLEA--VESKPHLHSPSDVGLDYAQYAQQY 527
            ..||           :.::..|.|.......|.||..  ...:...|||..  |:|:.:..|:
 Frog   351 HSLS-----------TINSEQSQSQQRTHIKTEQLSPSHYSDQQQQHSPQQ--LNYSSFNLQH 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox21bNP_001261829.1 SOX-TCF_HMG-box 247..318 CDD:238684 44/70 (63%)
sox9NP_001016853.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..66
Sox_N 22..94 CDD:403592
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436 63..103 0/2 (0%)
PQA. /evidence=ECO:0000250|UniProtKB:P48436 63..103 0/2 (0%)
SOX-TCF_HMG-box 104..174 CDD:238684 43/69 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..274 37/122 (30%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436 224..308 19/84 (23%)
9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436 276..285 0/8 (0%)
9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436 291..299 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..395 27/112 (24%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436 366..482 9/37 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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