DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox11

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001008053.1	Gene:	sox11 / 493415	XenbaseID:	XB-GENE-483418	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	312	Identity:	92/312 - (29%)
Similarity:	133/312 - (42%)	Gaps:	78/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 HIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKE 311
            |||||||||||||:::||||.:.:|.|||:|||||||..||:|.:.||.|||.||:|||..||.:
Frog    47 HIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLNDSEKIPFIREAERLRLKHMAD 111

  Fly   312 HPDYKYRPRRKPKALRRDGYPYPMPYPSVPVE-ALRAGITPGYFAPGPTAAAYHLGSHLGQTSTP 375
            :||||||||:|||.         .|..|.|.. |.....:|...:.|........|||.|.:|:
Frog   112 YPDYKYRPRKKPKV---------DPSASKPASLAQSPEKSPKSRSAGKKCPKLKPGSHSGSSSS- 166

  Fly   376 TTTQATLSGQMDKFALER----SSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDI 436
                   ||......::.    ..|:..|.:|::.:|        |..|   |.:|
Frog   167 -------SGSAKSLTIKSEYGGDDYVFGSPKAASKAA--------KCVF---MDED--------- 204

  Fly   437 SKIYGAQQHAAAHHQQQQQQQQQQQQQQQQL-------------LLSGGGGSGGGGSASSHNNNS 488
                 .::......:.:.|.:.:|:::.:.|             |.|....|..|.|......|.
Frog   205 -----DEEEEEDEEEDELQIRIKQEEEDEPLRQYNVAKVPASPTLSSSSAESAEGASMYEDVRNG 264

  Fly   489 S------SGLDDRDATPQL---------EAVESKPHLHSPS---DVGLDYAQ 522
            :      ..:..:...||.         .|..:.|..|...   |:.|::.|
Frog   265 TRLYYNFKNITKQSTIPQATITLAPAPRSAGTTSPSSHKDELMFDLSLNFTQ 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	47/70 (67%)
sox11	NP_001008053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		SOX-TCF_HMG-box	47..118	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..174		22/75 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..231		6/50 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010