Protein Alignment Sox21b and sox17a

DIOPT Version :10

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_989425.1
• Gene: sox17a / 395066
• XenbaseID: XB-GENE-484295
• Length: 383
• Species: Xenopus tropicalis
• Alignment Length: 381
• Identity: 105/381 - (27%)
• Similarity: 163/381 - (42%)
• Gaps: 75/381 - (19%)

  Fly   177 GGAANSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTK 241
            |.|::..:....|..:|...    |.....|.|:::|.:  |.|.:...||:           ::
 Frog     7 GYASDDQNQGKCSVPIMMTG----LGQCQWAEPMNSLGE--GKLKSDAGSAN-----------SR 54

  Fly   242 RQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRA 306
            .:.|..|:|||||||||::.:|:::||.||.:||:|:||.||..||.||..|||||::||:|||.
 Frog    55 GKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRV 119

  Fly   307 MHMKEHPDYKYRPRRKPKALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAAAYHLGSHLGQ 371
            .||::||:|||||||:.:..|.........:.:.|.|:...| |.|...    ..::.||.|
 Frog   120 QHMQDHPNYKYRPRRRKQVKRMKRADTGFMHMAEPPESAVLG-TDGRMC----LESFSLGYH--- 176

  Fly   372 TSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAY---------LDPSVLTKAYFDSKMYQD 427
                  .|.....|:.    :.|.|....:.|..|..|         ||.:.....:|.|.. ||
 Frog   177 ------EQTYPHSQLP----QGSHYREPQAMAPHYDGYSLPTPESSPLDLAEADPVFFTSPP-QD 230

  Fly   428 RAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGG-----------GSA 481
            ......:..:..|..||::.|....:|..|.:|..|...  :.|..|....           |||
 Frog   231 ECQMMPYSYNASYTHQQNSGASMLVRQMPQAEQMGQGSP--VQGMMGCQSSPQMYYGQMYLPGSA 293

  Fly   482 SSH-----NNNS----------SSGLDDRDATPQLEAVESKPHLH--SPSDVGLDY 520
            ..|     ..||          :..:...|...:::..|.:.:|.  :.||:|:.|
 Frog   294 RHHQLPQAGQNSPPPEAQQMGRADHIQQVDMLAEVDRTEFEQYLSYVAKSDLGMHY 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	47/78 (60%)
sox17a	NP_989425.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..58		5/33 (15%)
		HMG-box_SoxF_SOX17	55..135	CDD:438850	47/79 (59%)
		Sox17_18_mid	191..239	CDD:463454	10/48 (21%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	331..339		2/7 (29%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250|UniProtKB:Q3KQ35	332..337		1/4 (25%)