Protein Alignment Sox21b and sox17a

DIOPT Version :9

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_989425.1
• Gene: sox17a / 395066
• XenbaseID: XB-GENE-484295
• Length: 383
• Species: Xenopus tropicalis
• Alignment Length: 381
• Identity: 105/381 - (27%)
• Similarity: 163/381 - (42%)
• Gaps: 75/381 - (19%)

  Fly   177 GGAANSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTK 241
            |.|::..:....|..:|...    |.....|.|:::|.:  |.|.:...||:           ::
 Frog     7 GYASDDQNQGKCSVPIMMTG----LGQCQWAEPMNSLGE--GKLKSDAGSAN-----------SR 54

  Fly   242 RQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRA 306
            .:.|..|:|||||||||::.:|:::||.||.:||:|:||.||..||.||..|||||::||:|||.
 Frog    55 GKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRV 119

  Fly   307 MHMKEHPDYKYRPRRKPKALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAAAYHLGSHLGQ 371
            .||::||:|||||||:.:..|.........:.:.|.|:...| |.|...    ..::.||.|
 Frog   120 QHMQDHPNYKYRPRRRKQVKRMKRADTGFMHMAEPPESAVLG-TDGRMC----LESFSLGYH--- 176

  Fly   372 TSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAY---------LDPSVLTKAYFDSKMYQD 427
                  .|.....|:.    :.|.|....:.|..|..|         ||.:.....:|.|.. ||
 Frog   177 ------EQTYPHSQLP----QGSHYREPQAMAPHYDGYSLPTPESSPLDLAEADPVFFTSPP-QD 230

  Fly   428 RAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGG-----------GSA 481
            ......:..:..|..||::.|....:|..|.:|..|...  :.|..|....           |||
 Frog   231 ECQMMPYSYNASYTHQQNSGASMLVRQMPQAEQMGQGSP--VQGMMGCQSSPQMYYGQMYLPGSA 293

  Fly   482 SSH-----NNNS----------SSGLDDRDATPQLEAVESKPHLH--SPSDVGLDY 520
            ..|     ..||          :..:...|...:::..|.:.:|.  :.||:|:.|
 Frog   294 RHHQLPQAGQNSPPPEAQQMGRADHIQQVDMLAEVDRTEFEQYLSYVAKSDLGMHY 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	42/70 (60%)
sox17a	NP_989425.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..58		5/33 (15%)
		SOX-TCF_HMG-box	60..131	CDD:238684	42/70 (60%)
		Sox17_18_mid	191..239	CDD:371880	10/48 (21%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250|UniProtKB:Q3KQ35	332..337		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040