DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and sox7

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001074219.1	Gene:	sox7 / 394203	ZFINID:	ZDB-GENE-040109-4	Length:	390	Species:	Danio rerio

Alignment Length:	362	Identity:	93/362 - (25%)
Similarity:	139/362 - (38%)	Gaps:	128/362 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 NSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKRQNE 245
            :::.|.|.|....|..|.....|.|..:|...:                              :|
Zfish     6 SAYSSWPESFECSAGNADVPDGHTSHRAPADKV------------------------------SE 40

  Fly   246 EHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMK 310
            ..|:|||||||||::.:|:::|..||.:||:|:||.||..||.||..:|||:::||:|||..||:
Zfish    41 PRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTPPQKRPYVEEAERLRVQHMQ 105

  Fly   311 EHPDYKYRPRRKPKALRR------DGY--------PYPMPYPSVPVEAL----RAGITPGYFAPG 357
            ::|:|||||||| |.|:|      .|:        ...:|.|......|    .:|::.|:.:||
Zfish   106 DYPNYKYRPRRK-KQLKRICKRVDPGFLLTTLGPDQNSLPDPRGCCHPLDKDDESGVSGGFGSPG 169

  Fly   358 PTAAAYHLGSHLGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDS 422
                                  |.|.|    ..:.|....||||                  ||:
Zfish   170 ----------------------AALPG----VRVFRDPASSNSS------------------FDT 190

  Fly   423 KMYQDRAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNN 487
                     |.:.:..........|..|:.|...                  |.....::|..::
Zfish   191 ---------YPYGLPTPPEMSPLDAVDHEHQSYY------------------SSSSSVSTSSCSS 228

  Fly   488 SSSGLDDRDATPQLEAVESKPHLHSPSDVGLDYAQYA 524
            |:|..:||..||        .|:.||.....||:|.|
Zfish   229 SNSCPEDRRPTP--------AHMSSPPPYHPDYSQQA 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	38/70 (54%)
sox7	NP_001074219.1	SOX-TCF_HMG-box	42..113	CDD:238684	38/70 (54%)
sox7	NP_001074219.1	Sox_C_TAD	174..388	CDD:288887	27/141 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040