DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox8b

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001020636.1	Gene:	sox8b / 386704	ZFINID:	ZDB-GENE-031114-1	Length:	358	Species:	Danio rerio

Alignment Length:	323	Identity:	91/323 - (28%)
Similarity:	129/323 - (39%)	Gaps:	122/323 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :::.|:||||||||||::..|||:|...|.:||:|:||.||..|:||||.|||||::||:|||..
Zfish    81 KSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLTESEKRPFVEEAERLRVQ 145

  Fly   308 HMKEHPDYKYRPRRKPKALRRDGYPYPMPYPSVPVEALRAGITPGY---------------FAPG 357
            |.|:||||||:|||                        |..:.||:               ..||
Zfish   146 HKKDHPDYKYQPRR------------------------RKSVKPGHAESEAGSELMQHMYKAEPG 186

  Fly   358 P---TAAAYHLGSHLGQT---STPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLT 416
            .   |.:..|:..|.|.|   .||.||..|...|..|..::.|:              :|.|.|:
Zfish   187 MGRLTGSPDHITDHTGHTHGPPTPPTTPKTEHPQAPKQNIDFSN--------------VDISELS 237

  Fly   417 KAYFDSKMYQDRAANYAFDISKI-------------------YGAQQHAAAHHQQQQQQQQQQQQ 462
                     .|...|..||:.:.                   .||..|....|.:.:|:..|...
Zfish   238 ---------TDVIGNLTFDLQEFDQYLPLTPDQGACSRRAPPAGAHLHPQRVHIKTEQRSPQHYS 293

  Fly   463 QQQQLLLSGGGGSGGGGSASSHNNNSSSGLDDRDATPQLEAVESK------------PHLHSP 513
            :.               |::.::::|||.        |.|..|..            |:||.|
Zfish   294 EH---------------SSTLYSSSSSSA--------QCEYTEHSFYSPYSSYPYPYPYLHRP 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	45/70 (64%)
sox8b	NP_001020636.1	Sox_N	1..75	CDD:289229
sox8b	NP_001020636.1	SOX-TCF_HMG-box	85..155	CDD:238684	44/69 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810