DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox2

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_998283.1	Gene:	sox2 / 378723	ZFINID:	ZDB-GENE-030909-1	Length:	315	Species:	Danio rerio

Alignment Length:	361	Identity:	121/361 - (33%)
Similarity:	166/361 - (45%)	Gaps:	104/361 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 NMGSLMNSGSSASDVFFSLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISK 280
            |.|...|:.||.::           ::.:.:.|||||||||||||.||||:||:|||||||||||
Zfish    17 NTGGTGNTNSSGNN-----------QKNSPDRIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISK 70

  Fly   281 RLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKAL-RRDGYPYPMPYPSVPVEA 344
            |||||||||:|.||||||||||||||:|||||||||||||||.|.| ::|.|..|
Zfish    71 RLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLP---------- 125

  Fly   345 LRAGITPGYFAPGPT--AAAYHLGSHLGQTSTPTTTQATLSGQMDKFA-------------LERS 394
                  .|..|||..  .|...:|:.||         |.::.:||.:|             .|:.
Zfish   126 ------GGLLAPGGNGMGAGVGVGAGLG---------AGVNQRMDSYAHMNGWTNGGYGMMQEQL 175

  Fly   395 SYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDISKI-YGAQQHAAAHHQQQQQQQQ 458
            .|..:.|..:..:|.:.|.                  :.:|:|.: |.:..::..:.........
Zfish   176 GYPQHPSLNAHNTAQMQPM------------------HRYDMSALQYNSMTNSQTYMNGSPTYSM 222

  Fly   459 QQQQQQQQLLLSGGGGSGGGGSASS------HNNNSSSGL----DDRD--------ATPQLEAVE 505
            ...||....:..|..||.....:||      .:::|.:|.    |.||        |..|.::.:
Zfish   223 SYSQQSTPGMTLGSMGSVVKSESSSSPPVVTSSSHSRAGQCQTGDLRDMISMYLPGAEVQDQSAQ 287

  Fly   506 SKPHLHSPSDVGLDYAQYAQQYGGQLAAAAGGAVGG 541
            |:.|:             :|.|  |.|...|..:.|
Zfish   288 SRLHM-------------SQHY--QSAPVPGTTING 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	63/70 (90%)
sox2	NP_998283.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		7/34 (21%)
		SOX-TCF_HMG-box	37..108	CDD:238684	63/70 (90%)
		SOXp	107..197	CDD:289133	28/132 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..263		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..315		5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm26545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.870