DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and tcf7l1b

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_571371.2	Gene:	tcf7l1b / 30556	ZFINID:	ZDB-GENE-991110-10	Length:	550	Species:	Danio rerio

Alignment Length:	415	Identity:	95/415 - (22%)
Similarity:	154/415 - (37%)	Gaps:	114/415 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 HLHGQQLSLNHQHHHPHQSPQHQQQHQHHPCSSNSSNGSP---------NGSTGLGLHPHSALHL 114
            ||..:...:.|.|.|| .:|.....::..|       |:|         :..||:...||.| .|
Zfish   156 HLSNKVPVVQHAHMHP-LTPLITYSNEFPP-------GTPPAHLSPEILDPKTGIPRTPHPA-EL 211

  Fly   115 AHHH-------SQLHQHHPAG----QQQQHSQPPVSSSSTSHHSQSQALSHQTHSNGSSQLGGGS 168
            :.::       .|:  .||.|    ||.||.. |:::....|...:.|::....|..||:.
Zfish   212 SPYYPLSPGAVGQI--PHPLGWLVPQQGQHMY-PITAGGFRHPYPALAMNASMSSLVSSRF---- 269

  Fly   169 ASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLH--------HNSQASPISNLHQNMGSL---MN 222
                         |.|..|           .|.|        |.:..||:.....| |.|   :|
Zfish   270 -------------SPHLVP-----------HHPHGLHQTGIPHPAIVSPVIKQEPN-GELSPPVN 309

  Fly   223 SGSSASDVFFSLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWK 287
            :.|..         .|......:.|||:|:||||::.:..|.|:..:.....::.|::.||..|.
Zfish   310 TKSPG---------PNKKDEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWH 365

  Fly   288 LLTEEEKRPFIDEAKRLRAMHMKEHP------DYKYRPRRKPKALRRDGYPYPMPYPS------- 339
            .|:.||:..:.:.|::.|.:|.:.:|      :|..|.:|| :..:.|..|......|
Zfish   366 SLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRK-RDNKTDSTPEDFSMRSKKPCVQY 429

  Fly   340 VPVEAL--RAGITPGYFAPGPTAAAYHLGSHLGQTSTPTTTQATLSGQMDKFAL----ERSSYL- 397
            :|.|.:  ..|.:.|.....|...:..|.|       |....||.|.|....:|    ||...|
Zfish   430 LPQEKMIDSPGSSHGSMLDSPATPSAALAS-------PAAPAATHSEQAQPLSLTTKPERFPLLS 487

  Fly   398 -----SNSSQASAYSAYLDPSVLTK 417
                 |:||.:|:.|....|.:|::
Zfish   488 KPPPSSSSSSSSSSSGLPTPPLLSR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	22/76 (29%)
tcf7l1b	NP_571371.2	CTNNB1_binding	1..231	CDD:285538	19/85 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..326		6/37 (16%)
		SOX-TCF_HMG-box	325..396	CDD:238684	21/70 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960