DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox17

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_571362.2	Gene:	sox17 / 30544	ZFINID:	ZDB-GENE-991213-1	Length:	413	Species:	Danio rerio

Alignment Length:	319	Identity:	87/319 - (27%)
Similarity:	128/319 - (40%)	Gaps:	98/319 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            ::|..|:|||||||||::.:|:::||.||.:||:|:||.||..||.|...:||||::||:|||..
Zfish    58 KSEPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALPMVDKRPFVEEAERLRVK 122

  Fly   308 HMKEHPDYKYRPRRKPKALRR-------------------------------------------D 329
            ||::||:|||||||:.:..|.                                           :
Zfish   123 HMQDHPNYKYRPRRRKQVKRNKRLEPSFPLPGMCDAKMTLCTEGMSAGYSGAGLPQYCENHTLFE 187

  Fly   330 GYPYPMPYPSVPVEALRAGITPGYFAPGPTAAAY---HLGSH--------LGQTSTPTTTQATLS 383
            .|..|.|.|| |::   ||.|. :||.....:|:   |...|        |..|.....||...|
Zfish   188 SYSLPTPDPS-PMD---AGTTE-FFAQLQDQSAFSYHHQQEHHFQEQTNILNDTHCHGNTQTLKS 247

  Fly   384 GQMDKFALERSSYLSNSSQASAYSAYL------------------------------DPS----- 413
            .|....|....:..:||:..:..:|.|                              .||
Zfish   248 RQSHSIAYSNINTNTNSNLHAPINAQLSSINLQQVFHENANPQISHHPGTHLNIFNRSPSSSSHH 312

  Fly   414 VLTKAYFDSKMYQDRAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGG 472
            .:|.||.:.....|...|.:..:.::    .|..:.|..:||...:.|.|......|.|
Zfish   313 AMTPAYLNCPSTLDTFYNSSSQMKEL----SHCVSSHTHKQQSIAEAQSQASTATHSSG 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	40/70 (57%)
sox17	NP_571362.2	SOX-TCF_HMG-box	62..133	CDD:238684	40/70 (57%)
sox17	NP_571362.2	Sox_C_TAD	186..411	CDD:288887	40/191 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040