DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and tcf7l1a

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_571344.1	Gene:	tcf7l1a / 30523	ZFINID:	ZDB-GENE-980605-30	Length:	560	Species:	Danio rerio

Alignment Length:	496	Identity:	106/496 - (21%)
Similarity:	161/496 - (32%)	Gaps:	158/496 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HSHHLH--GQQLSLNHQHHHPHQSPQHQQQHQHHPCSSNSSNGSPNGSTGLGLHPHSALHLAHHH 118
            |.||:|  ...::.:::|..|...|.|.......|            .||:...||.
Zfish   166 HPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDP------------KTGIPRTPHP-------- 210

  Fly   119 SQLHQH------------HPAG----QQQQH--SQPPVSSSSTSHHSQSQALSHQTHSNGSSQLG 165
            |:|..:            ||.|    ||.||  |.||   ....|...:.|::....|..||:.
Zfish   211 SELSPYYPLSPGAVGQIPHPLGWLVPQQGQHMYSIPP---GGFRHPYPALAMNASMSSLVSSRF- 271

  Fly   166 GGSASGAGSVAGGAANSHHSAPASSSVMAAAAAAH----LH-----HNSQASPISNLHQNMGSLM 221
                            |.|..|            |    ||     |.:..||......|..|..
Zfish   272 ----------------SPHMVP------------HPPHGLHQTGIPHPAIVSPAIKQEPNGESPS 308

  Fly   222 NSGSSASDVFFSLMIQNTTKRQNEE--HIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGA 284
            ||......|        ..|::.|:  |||:|:||||::.:..|.|:..:.....::.|::.||.
Zfish   309 NSTHGKPSV--------PVKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGR 365

  Fly   285 EWKLLTEEEKRPFIDEAKRLRAMHMKEHPDY----KYRPRRKPKALRRDGYPYPMPYPSVPVEAL 345
            .|..|:.||:..:.:.|::.|.:|.:.:|.:    .|..|:|.|...:...|....:...|.:..
Zfish   366 RWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDCKSDSPSESNFSPQPKKQC 430

  Fly   346 RAGITPGYFAPGPTAAAYHLGSHLGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYL 410
            ...::.......||:      ||.....:|.|..|.|:              |.::.|:.:|...
Zfish   431 VPYLSSEKMCDSPTS------SHGSMLDSPATPSAALA--------------SPAAPAATHSEQA 475

  Fly   411 DPSVLTKAYFDSKMYQDRAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSG-GGG 474
            .|..||                         .:....|||            ......|.| ..|
Zfish   476 QPLSLT-------------------------TKPEGRAHH------------NHPHFPLPGKSSG 503

  Fly   475 SGGGGSASSHNNNSSSGLDDRDATPQLEAVESKPH---LHS 512
            ||.|.|.:.|  :.|..:......|.|....|..|   |||
Zfish   504 SGSGSSMALH--SLSRPIPFTSLPPSLLGPNSPFHQAALHS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	21/74 (28%)
tcf7l1a	NP_571344.1	CTNNB1_binding	1..233	CDD:285538	17/86 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..328		7/38 (18%)
		SOX-TCF_HMG-box	328..399	CDD:238684	21/70 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..513		30/174 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960