Protein Alignment Sox21b and Sox10

DIOPT Version :10

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_062066.1
• Gene: Sox10 / 29361
• RGDID: 3735
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 503
• Identity: 128/503 - (25%)
• Similarity: 193/503 - (38%)
• Gaps: 125/503 - (24%)

  Fly   147 SQSQALSHQTHSNGSSQ----LGGGSASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLHHNSQA 207
            ::.|.||....|...|:    |...||...|...||..:...::|....:   ........:.:|
  Rat     2 AEEQDLSEVELSPVGSEEPRCLSPSSAPSLGPDGGGGGSGLRASPGPGEL---GKVKKEQQDGEA 63

  Fly   208 S----PISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQ 268
            .    |:. :.:.:..:: ||...:.|...:.:...:|  ::.|:||||||||||::..|||:|.
  Rat    64 DDDKFPVC-IREAVSQVL-SGYDWTLVPMPVRVNGASK--SKPHVKRPMNAFMVWAQAARRKLAD 124

  Fly   269 DNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKALRRDGYPY 333
            ..|.:||:|:||.||..|:||.|.:|||||:||:|||..|.|:||||||:|||:.......|
  Rat   125 QYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQG--- 186

  Fly   334 PMPYPSVPVEALRAGITPGYFAPGPTAA--AYHLGSHL------------------------GQT 372
                     ||...|   |....|..||  |::..:||                        |..
  Rat   187 ---------EAECPG---GETDQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPEHPSGQSHGPP 239

  Fly   373 STPTTTQATL-SGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDI 436
            :.|||.:..| ||:.|.....||  |....               |.:.|       ..|  .||
  Rat   240 TPPTTPKTELQSGKADPKRDGRS--LGEGG---------------KPHID-------FGN--VDI 278

  Fly   437 SKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNNSSSGLDDRD----- 496
            .:|        :|......:.....:..|.|..:|..|..|..||:.:..:|:..:....
  Rat   279 GEI--------SHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLSSALAVASGHSAWIS 335

  Fly   497 -----ATPQLE--AVESK-------------PH-LHSPSDVGLDYAQYA-QQYGGQLAAAAGGAV 539
                 |.|.:.  ||::|             || ...||...:.|...: ..||....:.:....
  Rat   336 KPPGVALPTVSPPAVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQF 400

  Fly   540 GGG---AAGAAGGSAGGGSGGATAADF----RRPLTVIFXPPSSNGSE 580
            ...   .:|...|.||..||..:|..:    :|||.... .||.:|.:
  Rat   401 DYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQ 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	48/78 (62%)
Sox10	NP_062066.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		13/67 (19%)
		Sox_N	12..93	CDD:463586	14/85 (16%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693	62..102		6/43 (14%)
		HMG-box_SoxE	103..177	CDD:438840	46/73 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..198		18/52 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..275		13/85 (15%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693	228..310		22/115 (19%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693	353..466		21/96 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..375		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..466		6/16 (38%)