DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and Sry

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_035694.1	Gene:	Sry / 21674	MGIID:	98660	Length:	395	Species:	Mus musculus

Alignment Length:	289	Identity:	94/289 - (32%)
Similarity:	125/289 - (43%)	Gaps:	72/289 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 EEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHM 309
            |.|:||||||||||||.:|.|:||.||.|.|:||||:||..||.|||.|||||..||:||:.:|.
Mouse     2 EGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHR 66

  Fly   310 KEHPDYKYRPRRKPKALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAAAYHLGSHLGQTST 374
            :::|:|||:|.|:.|..:|.|...|....:.....|:       :...|.|..|
Mouse    67 EKYPNYKYQPHRRAKVSQRSGILQPAVASTKLYNLLQ-------WDRNPHAITY----------- 113

  Fly   375 PTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDISKI 439
                      :.|   ..|:::|.:.:|   .|.|..|..:...:...:..|.:
Mouse   114 ----------RQD---WSRAAHLYSKNQ---QSFYWQPVDIPTGHLQQQQQQQQ----------- 151

  Fly   440 YGAQQHAAAHHQQQQ------QQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNNSSSGLDDRDAT 498
               ||....||||||      ||||||||||||.              ..|:.......|.....
Mouse   152 ---QQQFHNHHQQQQQFYDHHQQQQQQQQQQQQF--------------HDHHQQKQQFHDHHQQQ 199

  Fly   499 PQLEAVESKPHLHSPSDVGLDYAQYAQQY 527
            .|..    ..|.|.......|:.|..||:
Mouse   200 QQFH----DHHHHHQEQQFHDHHQQQQQF 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	45/70 (64%)
Sry	NP_035694.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250\|UniProtKB:Q05066	4..81		48/76 (63%)
		SOX-TCF_HMG-box	4..74	CDD:238684	44/69 (64%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	6..22		13/15 (87%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250\|UniProtKB:Q05066	52..84		15/31 (48%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	75..81		2/5 (40%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269\|PubMed:15469996	92..144		11/85 (13%)
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269\|PubMed:16166090	94..138		11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..361		30/115 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910