Protein Alignment Sox21b and Sox18

DIOPT Version :9

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_033262.2
• Gene: Sox18 / 20672
• MGIID: 103559
• Length: 377
• Species: Mus musculus
• Alignment Length: 272
• Identity: 91/272 - (33%)
• Similarity: 128/272 - (47%)
• Gaps: 48/272 - (17%)

  Fly   178 GAANSHHSAPASS-SVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTK 241
            |||......|.:: |..:.|:.:.|..:...||.|..: ..|                  :...:
Mouse    27 GAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPESGRY-GFG------------------RGERQ 72

  Fly   242 RQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRA 306
            ..:|..|:|||||||||::.:|:::||.||.:||:.:||.||..||.|...|||||::||:|||.
Mouse    73 TADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRV 137

  Fly   307 MHMKEHPDYKYRPRRKPKA--LRR--DGYPYP-MPYPSVPVEALRAGI-TPGYFAPGPTAAAYHL 365
            .|:::||:||||||||.:|  :||  .|...| :..||.|.||..|.. :...|...||     |
Mouse   138 QHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPT-----L 197

  Fly   366 GSHLGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAA 430
            |:.......||..::.|.|      ||       ..:||.:...|.|.......|.:..    |.
Mouse   198 GAEFDGLGLPTPERSPLDG------LE-------PGEASFFPPPLAPEDCALRAFRAPY----AP 245

  Fly   431 NYAFDISKIYGA 442
            ..|.|.|..|||
Mouse   246 ELARDPSFCYGA 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	39/70 (56%)
Sox18	NP_033262.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		11/67 (16%)
		SOX-TCF_HMG-box	78..149	CDD:238684	39/70 (56%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	81..94		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	105..117		6/11 (55%)
		Important for transcriptional activation. /evidence=ECO:0000269|PubMed:10742113, ECO:0000269|PubMed:7651823	160..225		23/82 (28%)
		Sox_C_TAD	187..375	CDD:288887	23/93 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940