Protein Alignment Sox21b and Sox17

DIOPT Version :9

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001276393.1
• Gene: Sox17 / 20671
• MGIID: 107543
• Length: 419
• Species: Mus musculus
• Alignment Length: 433
• Identity: 114/433 - (26%)
• Similarity: 164/433 - (37%)
• Gaps: 145/433 - (33%)

  Fly   178 GAANSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKR 242
            |.|:...|.|.|:.....|...........||:.::......:.:||:.|.         .:.:.
Mouse     7 GYASDDQSQPRSAQPAVMAGLGPCPWAESLSPLGDVKVKGEVVASSGAPAG---------TSGRA 62

  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :.|..|:|||||||||::.:|:::||.||.:||:|:||.||..||.||..|||||::||:|||..
Mouse    63 KAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQ 127

  Fly   308 HMKEHPDYKYRPRRKP--KALRR--------------------------DGYPYPMPYPSVPVEA 344
            ||::||:|||||||:.  |.::|                          ||...|.|.|..|.
Mouse   128 HMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEPQAGALGPEGGRVAMDGLGLPFPEPGYPA-- 190

  Fly   345 LRAGITPGYFAPGPTAAAYHLGSH------LGQTS-----TPTTTQATLSGQMDKFALERSSYLS 398
                        ||...:.|:|.|      ||..:     .||...:.|.|      :|:
Mouse   191 ------------GPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSPLDG------VEQ----- 232

  Fly   399 NSSQASAYSAYLDPSVLTKAYFDSKMYQDRAA----------NYAFDISK--------------- 438
                        ||     |:|.:.:..|..|          :||..:..
Mouse   233 ------------DP-----AFFAAPLPGDCPAAGTYTYAPVSDYAVSVEPPAGPMRVGPDPSGPA 280

  Fly   439 -------------IYGAQQHAAA------HHQQQQ--QQQQQQQQQQQQLLLSGGGGSGGGGSA- 481
                         .|||....||      |.|.||  |.|......|||....|.|.......|
Mouse   281 MPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQAPPPPPQQQHPAHGPGQPSPPPEAL 345

  Fly   482 ----SSHNNNSSSGLDDRDATPQLEAVESKPHLHSPSDVGLDY 520
                .:.:|..:..|.:.|.|   |..:..|.::.| ::||.|
Mouse   346 PCRDGTESNQPTELLGEVDRT---EFEQYLPFVYKP-EMGLPY 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	42/70 (60%)
Sox17	NP_001276393.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		6/19 (32%)
		SOX-TCF_HMG-box	67..138	CDD:238684	42/70 (60%)
		Sox17_18_mid	203..253	CDD:403331	13/77 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..356		14/52 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940