Protein Alignment Sox21b and Sox10

DIOPT Version :10

• Sequence 1: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_035567.1
• Gene: Sox10 / 20665
• MGIID: 98358
• Length: 466
• Species: Mus musculus
• Alignment Length: 521
• Identity: 129/521 - (24%)
• Similarity: 191/521 - (36%)
• Gaps: 161/521 - (30%)

  Fly   147 SQSQALSHQTHSNGSSQ----LGGGSASGAGSVAGGAANSHHSAPASSSVMAAAAAAHLHHNSQA 207
            ::.|.||....|...|:    |..|||...|...||..:...::|....:   ........:.:|
Mouse     2 AEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGEL---GKVKKEQQDGEA 63

  Fly   208 S----PISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQ 268
            .    |:. :.:.:..:: ||...:.|...:.:...:|  ::.|:||||||||||::..|||:|.
Mouse    64 DDDKFPVC-IREAVSQVL-SGYDWTLVPMPVRVNGASK--SKPHVKRPMNAFMVWAQAARRKLAD 124

  Fly   269 DNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKALRRDGYPY 333
            ..|.:||:|:||.||..|:||.|.:|||||:||:|||..|.|:||||||:|||:.......|
Mouse   125 QYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQG--- 186

  Fly   334 PMPYPSVPVEALRAGITPGYFAPGPTAA--AYHLGSHL------------------------GQT 372
                     ||...|   |....|..||  |::..:||                        |..
Mouse   187 ---------EAECPG---GEAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPEHPSGQSHGPP 239

  Fly   373 STPTTTQATL-SGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANYAFDI 436
            :.|||.:..| ||:.|.....||  |....               |.:.|       ..|  .||
Mouse   240 TPPTTPKTELQSGKADPKRDGRS--LGEGG---------------KPHID-------FGN--VDI 278

  Fly   437 SKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNNSS------------ 489
            .:|        :|......:.....:..|.|..:|..|..|..||:.:...|:
Mouse   279 GEI--------SHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWIS 335

  Fly   490 ------------SGLD-------------------DRDATPQLEAVE-SKPHLHSP----SDVGL 518
                        .|:|                   |:.:|.|:.... |.||..|.    |....
Mouse   336 KPPGVALPTVSPPGVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQF 400

  Fly   519 DYAQYAQQYGGQLAAAAGGAVGGGAAGAAGGSAGGGSGGATAADF----RRPLTVIFXPPSSNGS 579
            ||:.:.                  .:|...|.||..||..:|..:    :|||.... .||.:|.
Mouse   401 DYSDHQ------------------PSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGP 447

  Fly   580 E 580
            :
Mouse   448 Q 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	48/78 (62%)
Sox10	NP_035567.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		14/67 (21%)
		Sox_N	12..93	CDD:463586	15/85 (18%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693	62..102		6/43 (14%)
		HMG-box_SoxE	103..177	CDD:438840	46/73 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..200		19/54 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..275		13/85 (15%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693	228..310		22/115 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..375		3/30 (10%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693	353..466		23/114 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..466		6/16 (38%)