DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and sox10

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_571950.1	Gene:	sox10 / 140616	ZFINID:	ZDB-GENE-011207-1	Length:	485	Species:	Danio rerio

Alignment Length:	539	Identity:	135/539 - (25%)
Similarity:	200/539 - (37%)	Gaps:	171/539 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QQHSQPPVSSS---STSHHSQSQALSHQTHSNGS------------SQLGGGSASGAGSVAGGAA 180
            ::||...|..|   |...||.|..     ||:|:            ||:.|....||| |:||.:
Zfish     4 EEHSMSEVEMSPGVSDDGHSMSPG-----HSSGAPGGADSPLPGQQSQMSGIGDDGAG-VSGGVS 62

  Fly   181 NSHHSAPASSSVMAAAAAAHLHHNSQASPISNLHQNMGSLMNSGSSASDVFFSLMIQNTTKRQNE 245
            ...........:....|.:.:.:....:.:.     |...:||||                 :::
Zfish    63 VKSDEEDDRFPIGIREAVSQVLNGYDWTLVP-----MPVRVNSGS-----------------KSK 105

  Fly   246 EHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMK 310
            .|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.:|||||:||:|||..|.|
Zfish   106 PHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNETDKRPFIEEAERLRKQHKK 170

  Fly   311 EHPDYKYRPRRKPKALRRDGYP----------------YPMPYPSVPVEALRAGITPGYFAPGPT 359
            ::|:|||:|||     |::|.|                ....|.|:.:|....|.     |..|.
Zfish   171 DYPEYKYQPRR-----RKNGKPGSSSEADAHSEGEVSHSQSHYKSLHLEVAHGGA-----AGSPL 225

  Fly   360 AAAYH---LGSHLGQTSTPTTTQATLSGQMD-----KFALERSSY------LSNSSQASA----- 405
            ...:|   .|......:.|||.:..|.|...     :....||..      .|.||.||.
Zfish   226 GDGHHPHATGQSHSPPTPPTTPKTELQGGKSGEGKREGGASRSGLGVGADGSSASSSASGKPHID 290

  Fly   406 ------------------------YSAYLDPSVLTKAYFDSKMYQDRAANYAFDISK-IYGAQQH 445
                                    :..||.|:...:|...:.. ...|.:|.:.||. :..|..|
Zfish   291 FGNVDIGEISHDVMANMEPFDVNEFDQYLPPNGHPQASATASA-GSAAPSYTYGISSALAAASGH 354

  Fly   446 AAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGG-----------GGSASSHNNNSSSGLDDRDATP 499
            :.|...:||...||..           |..||           |.:|:|.::.:.:.|
Zfish   355 STAWLSKQQLPSQQHL-----------GADGGKTQIKSETHFPGDTAASGSHVTYTPL------- 401

  Fly   500 QLEAVESKPHLHS--PSDVG-LDYAQYAQQYGGQLAAAAGGAVGGGAAGAAGGSAGGGSGGATAA 561
                  :.||..|  ||... ..:|:||:..               |:|:....:...||..:|.
Zfish   402 ------TLPHYSSAFPSLASRAQFAEYAEHQ---------------ASGSYYAHSSQTSGLYSAF 445

  Fly   562 DF----RRPLTVIFXPPSS 576
            .:    :|||......|.|
Zfish   446 SYMGPSQRPLYTAIPDPGS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	42/70 (60%)
sox10	NP_571950.1	Sox_N	13..97	CDD:289229	19/94 (20%)
sox10	NP_571950.1	SOX-TCF_HMG-box	107..177	CDD:238684	41/69 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810