DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sox21b and Sox9

DIOPT Version :9

Sequence 1:NP_001261829.1 Gene:Sox21b / 39569 FlyBaseID:FBgn0042630 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_536328.1 Gene:Sox9 / 140586 RGDID:620474 Length:507 Species:Rattus norvegicus


Alignment Length:381 Identity:111/381 - (29%)
Similarity:157/381 - (41%) Gaps:104/381 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :|:.|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.|||||::||:|||..
  Rat   100 KNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQ 164

  Fly   308 HMKEHPDYKYRPRRKP------------------------KALRRDGYPYPMPYPSVPVEALRAG 348
            |.|:||||||:|||:.                        |||:.|.     |:.|       :|
  Rat   165 HKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADS-----PHSS-------SG 217

  Fly   349 ITPGYFAPGPTAAAYHLGSHLGQTSTPTTTQATLSGQMDKFALER-------------------- 393
            ::..: :||.     |.|...|..:.|||.:..:  |..|..|:|                    
  Rat   218 MSEVH-SPGE-----HSGQSQGPPTPPTTPKTDV--QAGKVDLKREGRPLAEGGRQPPIDFRDVD 274

  Fly   394 -----SSYLSN--SSQASAYSAYLDPS------------VLTKAYFDSKMYQDRAANYAFDISKI 439
                 |..:||  :...:.:..||.|:            ..|.:|..|......|......:||.
  Rat   275 IGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVSYTGSYGISSTAPTPATAGHVWMSKQ 339

  Fly   440 YG----------AQQHAAAHHQQQQQQQQQQQQQQQQ----LLLSGGGGSGGGGSASSHNNNSSS 490
            ..          |.|...|..|||...|.||..||||    ..||...|........:...:.|.
  Rat   340 QAPPPPPQQPPQAPQAPQAPPQQQAPPQPQQAPQQQQAHTLTTLSSEPGQSQRTHIKTEQLSPSH 404

  Fly   491 GLDDRDATPQLEAVE--SKPHLHSPSDVGLDYAQY----AQQYGGQLAAAAGGAVG 540
            ..:.:..:||..:..  :.|| ::||...:..:||    .|..|...:.|||...|
  Rat   405 YSEQQQHSPQQISYSPFNLPH-YNPSYPTITRSQYDYTDHQNSGSYYSHAAGQGSG 459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox21bNP_001261829.1 SOX-TCF_HMG-box 247..318 CDD:238684 44/70 (63%)
Sox9NP_536328.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67
Sox_N 22..94 CDD:403592
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436 63..103 1/2 (50%)
PQA. /evidence=ECO:0000250|UniProtKB:P48436 63..103 1/2 (50%)
SOX-TCF_HMG-box 104..174 CDD:238684 43/69 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..271 33/130 (25%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436 224..307 18/89 (20%)
9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436 275..284 1/8 (13%)
9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436 290..298 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..429 23/94 (24%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436 392..507 15/69 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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