DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21b and sox8a

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001271361.1	Gene:	sox8a / 102216265	ZFINID:	ZDB-GENE-130530-719	Length:	401	Species:	Danio rerio

Alignment Length:	309	Identity:	88/309 - (28%)
Similarity:	141/309 - (45%)	Gaps:	69/309 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 IQNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDE 300
            :|.:...:::.|:||||||||||::..|||:|...|.:||:|:||.||..|:||:|.|||||::|
Zfish    74 MQGSRSLKDKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEE 138

  Fly   301 AKRLRAMHMKEHPDYKYRPRR----KPKALRRDGYPYPMPYPSVPVEALRAGITPGYFAPGPTAA 361
            |:|||..|.|::|||||:|||    ||.....:.......:.:.|:....||:          .|
Zfish   139 AERLRLQHKKDYPDYKYQPRRRKSLKPGQNEAEAGAEKNLHHTDPIYKTEAGM----------RA 193

  Fly   362 AYHLGSH----LGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDS 422
            .:|...|    .|..:.|||.::.....|.:        ||.:::.:...:.:|.|.|:.....|
Zfish   194 MHHQTIHGVQPHGPPTPPTTPKSDQHQSMKR--------LSENARQNIDFSNVDISELSSDVIGS 250

  Fly   423 KMYQDRAANYAFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGGG-------S 480
            ..        .||:                        ::..|.|.|:|...||||.       |
Zfish   251 IS--------QFDV------------------------REFDQYLPLNGHTESGGGQHSSPGCFS 283

  Fly   481 ASSHNNNSSSGLDDRDATPQL-EAVESKPHLHSPSDVGLDYAQYAQQYG 528
            .|.|:::.:|..:....:|.. .|.:.:|.:.:..   |..:.|.|.:|
Zfish   284 TSFHHHSGASAWNKPSGSPSTSSANQQRPLIKTEQ---LSPSHYGQSHG 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	43/70 (61%)
sox8a	NP_001271361.1	Sox_N	<40..73	CDD:372113
sox8a	NP_001271361.1	SOX-TCF_HMG-box	85..155	CDD:238684	42/69 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910