DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21b and sox10

DIOPT Version :9

Sequence 1:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001093691.1	Gene:	sox10 / 100101700	XenbaseID:	XB-GENE-480304	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	361	Identity:	96/361 - (26%)
Similarity:	128/361 - (35%)	Gaps:	169/361 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 QNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAM 307
            :::.|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.:|||||:||:|||..
Frog    85 KSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQ 149

  Fly   308 HMKEHPDYKYRPRR----KPKALRRDG-------------------------------------- 330
            |.|:||||||:|||    ||.....||
Frog   150 HKKDHPDYKYQPRRRKNGKPNPGEGDGSSEAEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSAG 214

  Fly   331 --YPYPMPYPSVPVEALRAGITPG----------------------------------------- 352
              :..|.| |:.|...|:||.:.|
Frog   215 QSHGPPTP-PTTPKTELQAGKSDGKRDGSRSLGEGGKPHIDFGNVDIGEISHDVMANMETFDVNE 278

  Fly   353 ---YFAP-GPTAAAYHLGSHLGQ---------------------------------------TST 374
               |..| |......|:|.:...                                       |..
Frog   279 FDQYLPPNGHAGHPSHIGGYTSSYGLSGALAAGPSAWALAKQHPQTDSKAQVKTESSSTSHYTEQ 343

  Fly   375 PTTTQATLSG----------------QMDKFALER--SSYLSNSSQASA-YSA--YLDP--SVLT 416
            |:|:|.|.:.                |.| :|..:  |||.|:|||||: |||  |:.|  ..|.
Frog   344 PSTSQLTYTSLGLPHYGSAFPSISRPQFD-YADHQPSSSYYSHSSQASSLYSAFSYMGPPQRPLY 407

  Fly   417 KAYFDSKMYQDRAANYAFDISKIYGAQQHAAAHHQQ 452
            .|..||...                ||.|:..|.:|
Frog   408 TAISDSPSV----------------AQSHSPTHWEQ 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	44/70 (63%)
sox10	NP_001093691.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Sox_N	12..79	CDD:372113
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	48..88		0/2 (0%)
		SOX-TCF_HMG-box	89..159	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		18/37 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..257		8/62 (13%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	209..295		11/86 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..346		2/23 (9%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	327..436		31/118 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436		6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910