DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21a and sox1

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001074465.1	Gene:	sox1 / 779569	XenbaseID:	XB-GENE-1018269	Length:	401	Species:	Xenopus tropicalis

Alignment Length:	330	Identity:	142/330 - (43%)
Similarity:	169/330 - (51%)	Gaps:	88/330 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NAPTSHSNSNT------GSHHNSHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEW 159
            ::|.....|||      |.:..:.|.:||||||||||||||||||||:|||||||||||||||||
Frog    11 HSPGVQPPSNTGQTGGGGGNKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 75

  Fly   160 KLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTL---NKSPVPGG-----GGG------ 210
            |:::|.:|||||||||||||||||||||||||||||.|||   :|..:.||     |||
Frog    76 KVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLHAAGGGHMGVGL 140

  Fly   211 --GGGGGANGGV------------NAGGAG--NSGPSG--PGSVGSP------KDMQPQLSPLGQ 251
              |||||..|||            :|||..  |...:|  ||||.:.      ::.|...|...|
Frog   141 SPGGGGGGTGGVVVQRLESPGSGASAGGYAHMNGWANGAYPGSVAAAAAAAMMQEAQLAYSQQQQ 205

  Fly   252 SLPHLHG-HPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPLELSLPRLPNAFPGLAHYPL 315
            ..|...| |||..|:..| ||||.||||                          |..|.....|.
Frog   206 QHPGSGGHHPHHHPHHPH-HHPHHHPHH--------------------------NPTPHPPPPPP 243

  Fly   316 DPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYGCVKSE-KSSP-NAVV 378
            .|....|:.| ||            |.||...:|..: .|.||.|...|...:.: :.|| :|.|
Frog   244 QPMHRYDMSA-LQ------------YSPLPGAQTYMT-ASPSGYGALGYSSSQQQHQGSPSSAAV 294

  Fly   379 ASAAS 383
            |:||:
Frog   295 AAAAA 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	62/70 (89%)
sox1	NP_001074465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		6/26 (23%)
		SOX-TCF_HMG-box	36..107	CDD:238684	62/70 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..249		22/78 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4714
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010