Protein Alignment Sox21a and SOX15

DIOPT Version :9

• Sequence 1: NP_001261827.1
• Gene: Sox21a / 39567
• FlyBaseID: FBgn0036411
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_008873.1
• Gene: SOX15 / 6665
• HGNCID: 11196
• Length: 233
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 99/232 - (42%)
• Similarity: 123/232 - (53%)
• Gaps: 52/232 - (22%)

  Fly   102 APTSHSNSNTGSHHNSH------------DHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKR 154
            |.|:.::|::|......            :.:|||||||||||..|||:|||.||||||||||||
Human    18 AATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKR 82

  Fly   155 LGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGGGANGG 219
            |||:||||.|.:||||::|||||||.|::::||||||||||.|:....  |...|.|.|..|:||
Human    83 LGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAG--PSRCGQGRGNLASGG 145

  Fly   220 VNAG----------GAGNSGPSG-----PGSVGSP--KDMQPQLSPLGQSLPHLHG-----HPHQ 262
            ...|          |.|...||.     |||.||.  |...|....|.||.|.|.|     :.|.
Human   146 PLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHY 210

  Fly   263 SPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPLELS 299
            .|..|      |.|::..||          |:|:.|:
Human   211 LPPGS------PTPYNPPLA----------GAPMPLT 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	53/70 (76%)
SOX15	NP_008873.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48		4/29 (14%)
		Required to promote HAND1 transcriptional activator activity. /evidence=ECO:0000250|UniProtKB:P43267	1..47		4/28 (14%)
		SOX-TCF_HMG-box	48..119	CDD:238684	53/70 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..153		19/41 (46%)
		Interaction with FHL3. /evidence=ECO:0000250|UniProtKB:P43267	138..183		14/44 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..233		10/40 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840