DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and SOX10

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_008872.1	Gene:	SOX10 / 6663	HGNCID:	11190	Length:	466	Species:	Homo sapiens

Alignment Length:	335	Identity:	107/335 - (31%)
Similarity:	138/335 - (41%)	Gaps:	113/335 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALH 181
            |..|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|..|||||:||:|||..|
Human   100 SKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQH 164

  Fly   182 MKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGGGANGGVNAGGA---------GNSGPSGPGSVG 237
            .|:||||||:|||:.   |.....|.....||....||..|..|         .:.|...|.|.|
Human   165 KKDHPDYKYQPRRRK---NGKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDG 226

  Fly   238 SPKDMQPQLSPLGQSLPHLHGHP-----HQSPYQS----------------HPH----------- 270
            :|:      .|.|||    ||.|     .::..||                .||
Human   227 NPE------HPSGQS----HGPPTPPTTPKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEI 281

  Fly   271 -H-------------------PHPHPHHVQLAAATLSAKYGFGSPLE--------LSLPRLPNAF 307
             |                   |:.||.||...:|   |.||.||.|.        :|.|
Human   282 SHEVMSNMETFDVAELDQYLPPNGHPGHVSSYSA---AGYGLGSALAVASGHSAWISKP------ 337

  Fly   308 PGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPP---SPPSSSGTGISS-----Y 364
            ||:|...:.|. .:|.:|:::...||             |:.||   ..||:|....:|     |
Human   338 PGVALPTVSPP-GVDAKAQVKTETAG-------------PQGPPHYTDQPSTSQIAYTSLSLPHY 388

  Fly   365 GCVKSEKSSP 374
            |......|.|
Human   389 GSAFPSISRP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	44/70 (63%)
SOX10	NP_008872.1	Sox_N	12..93	CDD:315171
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	62..102		1/1 (100%)
		SOX-TCF_HMG-box	103..173	CDD:238684	43/69 (62%)
		Nuclear export signal	134..145		5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..199		17/41 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..274		16/71 (23%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	228..310		16/91 (18%)
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	353..466		14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..375		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740