DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21a and SOX9

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens

Alignment Length:	495	Identity:	124/495 - (25%)
Similarity:	162/495 - (32%)	Gaps:	176/495 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSISALLHRSHSHSNGYTSSGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTT 65
            |..:...:..:.....|.:.:.|...|..|:.|| .|.                 |.||.:.||.
Human     1 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSP-CPS-----------------GSGSDTENTR 47

  Fly    66 PP----PMPPADL---------------AVPPA--------APTPVAPKMHQHTHHHGNSHHNAP 103
            |.    |....||               ||...        .|.||         ....|..|.|
Human    48 PQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPV---------RVNGSSKNKP 103

  Fly   104 TSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKR 168
                            |:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.:||
Human   104 ----------------HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKR 152

  Fly   169 PFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGP 233
            ||::||:|||..|.|:||||||:|||:...                 .||...|..|.......|
Human   153 PFVEEAERLRVQHKKDHPDYKYQPRRRKSV-----------------KNGQAEAEEATEQTHISP 200

  Fly   234 GSVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPL-- 296
            .::..........|..|.|..|..|. |....|..|..|......||...|.|..:   |.||
Human   201 NAIFKALQADSPHSSSGMSEVHSPGE-HSGQSQGPPTPPTTPKTDVQPGKADLKRE---GRPLPE 261

  Fly   297 ---------------ELS------------------LPRLPNAFPGL----------AHYPLDPT 318
                           |||                  ||  ||..||:          ..|.:..|
Human   262 GGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLP--PNGHPGVPATHGQVTYTGSYGISST 324

  Fly   319 LALDLQARLQAMYAGSIYHPWRYLPLISPETPP-SPPS--------------------------- 355
            .|....       ||.::...:..|...|:.|| :||:
Human   325 AATPAS-------AGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTL 382

  Fly   356 ---SSGTGISSYGCVKSEKSSPNAVVASAASPPNIIXPTP 392
               ||..|.|....:|:|:.||:.........|..|..:|
Human   383 TTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	43/70 (61%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		17/83 (20%)
		Sox_N	22..94	CDD:403592	20/98 (20%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		7/48 (15%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		7/48 (15%)
		SOX-TCF_HMG-box	104..174	CDD:238684	42/69 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		35/133 (26%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		21/88 (24%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284		3/8 (38%)
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415		16/91 (18%)
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740