Protein Alignment Sox21a and SOX3

DIOPT Version :9

• Sequence 1: NP_001261827.1
• Gene: Sox21a / 39567
• FlyBaseID: FBgn0036411
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 134/391 - (34%)
• Similarity: 161/391 - (41%)
• Gaps: 142/391 - (36%)

  Fly    68 PMPPADLA-----------------VPPAAPT-------PVAPKMHQHTHHHGNSHHNAPTSHSN 108
            |.|||.||                 .|...||       |.||      ...|.|..|| ...:|
Human    61 PSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAP------GGAGKSSANA-AGGAN 118

  Fly   109 SNTGSHHNS--------HDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEG 165
            |..||...:        .|.:|||||||||||||||||||.:|||||||||||||||:|||||:.
Human   119 SGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDA 183

  Fly   166 QKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTL---NKSPVPGGGGGGGGGGANGGVNAGGAGN 227
            :|||||||||||||:||||:||||||||||.|||   :|..:|.|....|...|.....|..|..
Human   184 EKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAA 248

  Fly   228 SGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGF 292
            |.|.|   ||...|          :..|::|..:.                   |.:.:..:.|:
Human   249 SSPVG---VGQRLD----------TYTHVNGWANG-------------------AYSLVQEQLGY 281

  Fly   293 GSPLELSLPRLPNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPPS----- 352
            ..|..:|.|..|.|.|.:..|.:                ||..|         ||..||.
Human   282 AQPPSMSSPPPPPALPPMHRYDM----------------AGLQY---------SPMMPPGAQSYM 321

  Fly   353 ---------------PPSSSGTGISSYG-----------------------CVKSEKSSPNAVVA 379
                           .||::....::||                       .||||.|||...:|
Human   322 NVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIA 386

  Fly   380 S 380
            |
Human   387 S 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	60/70 (86%)
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		15/59 (25%)
		SOX-TCF_HMG-box	138..209	CDD:238684	60/70 (86%)
		SOXp	208..302	CDD:289133	32/125 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840