Protein Alignment Sox21a and SOX17

DIOPT Version :10

• Sequence 1: NP_001261827.1
• Gene: Sox21a / 39567
• FlyBaseID: FBgn0036411
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_071899.1
• Gene: SOX17 / 64321
• HGNCID: 18122
• Length: 414
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 122/467 - (26%)
• Similarity: 162/467 - (34%)
• Gaps: 179/467 - (38%)

  Fly    17 GYTSSGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTTPPP-----MPPADLAV 76
            ||.|...|....:      ||.:..|||                     |.|     .|..|:.|
Human     7 GYASDDQSQTQSA------LPAVMAGLG---------------------PCPWAESLSPIGDMKV 44

  Fly    77 PPAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQ 141
            ...||                ::..||...:....|     ...|:|||||||||::.:|:::||
Human    45 KGEAP----------------ANSGAPAGAAGRAKG-----ESRIRRPMNAFMVWAKDERKRLAQ 88

  Fly   142 DNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPG 206
            .||.:||:|:||.||..||.||..:||||::||:|||..||::||:|||||||:.:......|.|
Human    89 QNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEG 153

  Fly   207 GG------------GGGGGGGANGGVNAGGAGNSGPSGP--------------GSVGSPK----- 240
            |.            |..||..|..|:.........|:||              .|:|:|.
Human   154 GFLHGLAEPQAAALGPEGGRVAMDGLGLQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYP 218

  Fly   241 --------------------------------------------------DMQPQL--SPLGQSL 253
                                                              .|.|:|  .|.|.|:
Human   219 LPTPDTSPLDGVDPDPAFFAAPMPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSI 283

  Fly   254 PHLHGHPHQ---------SP-------YQSHP--HHPHPHPHHVQLAAATLSAKYGFGSPLELSL 300
            |.|...|..         ||       :|..|  .|.|.|.||..          |.|.|   |.
Human   284 PGLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPP----------GPGQP---SP 335

  Fly   301 PRLPNAFPGLAHYPLDPTLALDLQARLQ----AMYAGSIYHPWRYLPLISPETPPSPPSSSGTGI 361
            |  |.|.|  .....||:...:|...:.    ..|...:..|...||....::..:.|.|.| .|
Human   336 P--PEALP--CRDGTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHG-AI 395

  Fly   362 SSYGCVKSEKSS 373
            ||   |.|:.||
Human   396 SS---VVSDASS 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	HMG-box_SoxB	119..198	CDD:438790	46/78 (59%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..66		8/50 (16%)
		HMG-box_SoxF_SOX17	62..142	CDD:438850	46/84 (55%)
		Sox17_18_mid	203..253	CDD:463454	3/49 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..352		17/63 (27%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	361..369		1/7 (14%)