DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and sox9

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001016853.1	Gene:	sox9 / 549607	XenbaseID:	XB-GENE-1034769	Length:	482	Species:	Xenopus tropicalis

Alignment Length:	302	Identity:	95/302 - (31%)
Similarity:	135/302 - (44%)	Gaps:	68/302 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALH 181
            |..|:||||||||||::..|||:|...|.:||:|:||.||..|:||.||:||||::||:|||..|
Frog   101 SKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRIQH 165

  Fly   182 MKEHPDYKYRPRRKPKTLNKSPVPGGGG-----------------GGGGGGANGGVNAGG--AGN 227
            .|:||||||:|||:....|.......|.                 ......:...|::.|  :|.
Frog   166 KKDHPDYKYQPRRRKSVKNGQSEQEDGAEQTHISPNAIFKALQADSPHSASSMSEVHSPGEHSGQ 230

  Fly   228 S-GPSGPGSVGSPK-DMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKY 290
            | ||..|.:  :|| |:||....|.:     .|.|.|...:..||.........:|::..:|...
Frog   231 SQGPPTPPT--TPKTDVQPGKPDLKR-----EGRPLQESGRQPPHIDFRDVDIGELSSEVISTIE 288

  Fly   291 GFG-SPLELSLPRLPNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISP------- 347
            .|. :..:..||  ||..||:              ...||.|.||  :.....|..:|
Frog   289 TFDVNEFDQYLP--PNGHPGV--------------GSTQAPYTGS--YGINSTPSATPGAGPAWM 335

  Fly   348 -------ETPPSPPSSSGTGISSYGC-------VKSEKSSPN 375
                   :..|.||..|.:.|:|...       :|:|:.||:
Frog   336 SKQQQQQQQQPQPPQHSLSTINSEQSQSQQRTHIKTEQLSPS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	44/70 (63%)
sox9	NP_001016853.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Sox_N	22..94	CDD:403592
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		1/1 (100%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		1/1 (100%)
		SOX-TCF_HMG-box	104..174	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..274		34/120 (28%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..308		26/106 (25%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	276..285		1/8 (13%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	291..299		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..395		23/101 (23%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	366..482		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910