DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and sox17a

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_989425.1	Gene:	sox17a / 395066	XenbaseID:	XB-GENE-484295	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	290	Identity:	84/290 - (28%)
Similarity:	131/290 - (45%)	Gaps:	61/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SNTGSHHN---SHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPF 170
            |:.||.::   :...|:|||||||||::.:|:::||.||.:||:|:||.||..||.||..:||||
Frog    46 SDAGSANSRGKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPF 110

  Fly   171 IDEAKRLRALHMKEHPDYKYRPRRKP--KTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGP 233
            ::||:|||..||::||:|||||||:.  |.:.::                  :.|....:.|...
Frog   111 VEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRA------------------DTGFMHMAEPPES 157

  Fly   234 GSVGSPKDMQPQLSPLG---QSLPHL---HGHPHQSPYQSHPHH-----PHPHPHHVQLAAATLS 287
            ..:|:...|..:...||   |:.||.   .|..::.|....||:     |.|....:.||.|.
Frog   158 AVLGTDGRMCLESFSLGYHEQTYPHSQLPQGSHYREPQAMAPHYDGYSLPTPESSPLDLAEAD-- 220

  Fly   288 AKYGFGSPLELSLPRLPNAFPGLAHYPLDPTLALDLQARLQA--------------------MYA 332
             ...|.||.:.....:|.::.....:..:...::.::...||                    ||.
Frog   221 -PVFFTSPPQDECQMMPYSYNASYTHQQNSGASMLVRQMPQAEQMGQGSPVQGMMGCQSSPQMYY 284

  Fly   333 GSIYHP----WRYLPLISPETPPSPPSSSG 358
            |.:|.|    ...||.....:||......|
Frog   285 GQMYLPGSARHHQLPQAGQNSPPPEAQQMG 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	41/70 (59%)
sox17a	NP_989425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..58		3/11 (27%)
		SOX-TCF_HMG-box	60..131	CDD:238684	41/70 (59%)
		Sox17_18_mid	191..239	CDD:371880	12/50 (24%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250\|UniProtKB:Q3KQ35	332..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040