DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and sox2

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_998283.1	Gene:	sox2 / 378723	ZFINID:	ZDB-GENE-030909-1	Length:	315	Species:	Danio rerio

Alignment Length:	331	Identity:	132/331 - (39%)
Similarity:	155/331 - (46%)	Gaps:	111/331 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQD 142
            |.||.|                :...|.::||:..:..||.|.|||||||||||||||||||||:
Zfish    11 PPAPQP----------------NTGGTGNTNSSGNNQKNSPDRIKRPMNAFMVWSRGQRRKMAQE 59

  Fly   143 NPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTL---NKSPV 204
            ||||||||||||||||||||:|.:|||||||||||||||||||||||||||||.|||   :|..:
Zfish    60 NPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 124

  Fly   205 PGG--GGGGGGGGANGGVNAG-GAGNSGPSGPGSVGSPKDMQPQLSPLGQSLPHLH-----GHPH 261
            |||  ..||.|.||..||.|| |||         |....|          |..|::     |:..
Zfish   125 PGGLLAPGGNGMGAGVGVGAGLGAG---------VNQRMD----------SYAHMNGWTNGGYGM 170

  Fly   262 QSPYQSHPHHPHPHPHH--------------VQLAAATLSAKYGFGSPLELSLPRLPNAFPGLAH 312
            ......:|.||..:.|:              :|..:.|.|..|..|||
Zfish   171 MQEQLGYPQHPSLNAHNTAQMQPMHRYDMSALQYNSMTNSQTYMNGSP----------------- 218

  Fly   313 YPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYG-CVKSEKSSPNA 376
                             .|:.|.                |..|:.|..:.|.| .||||.||...
Zfish   219 -----------------TYSMSY----------------SQQSTPGMTLGSMGSVVKSESSSSPP 250

  Fly   377 VVASAA 382
            ||.|::
Zfish   251 VVTSSS 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	65/70 (93%)
sox2	NP_998283.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		12/45 (27%)
		SOX-TCF_HMG-box	37..108	CDD:238684	65/70 (93%)
		SOXp	107..197	CDD:289133	34/108 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..263		11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582399
Domainoid	1	1.000	141	1.000	Domainoid score	I4650
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm25204
orthoMCL	1	0.900	-	-		OOG6_106862
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790