DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and SOX8

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_055402.2	Gene:	SOX8 / 30812	HGNCID:	11203	Length:	446	Species:	Homo sapiens

Alignment Length:	419	Identity:	121/419 - (28%)
Similarity:	165/419 - (39%)	Gaps:	110/419 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TSSGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTTPPPMPPADLAVPPA---- 79
            |:|..|:...|.|.:|..|..:.|||..|       |.||...|:    |...||...|..
Human    18 TASSMSHVEDSDSDAPPSPAGSEGLGRAG-------VAVGGARGD----PAEAADERFPACIRDA 71

  Fly    80 ------------APTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWS 132
                        .|.||                       ....|....:..|:||||||||||:
Human    72 VSQVLKGYDWSLVPMPV-----------------------RGGGGGALKAKPHVKRPMNAFMVWA 113

  Fly   133 RGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 197
            :..|||:|...|.:||:|:||.||..|:||:|.:||||::||:|||..|.|:||||||:|||:
Human   114 QAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRR-- 176

  Fly   198 TLNKSPVPGGGGGGGGG--GANGGVNAGGAGNSGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHP 260
               ||...|......|.  |.:.|   |||.....:|.|.                      ||
Human   177 ---KSAKAGHSDSDSGAELGPHPG---GGAVYKAEAGLGD----------------------GH- 212

  Fly   261 HQSPYQSHPHHP--HPHPHHVQLAAATLSAKYGFGSPLELSLPRLPNAFPGLAHYPLDPTLALDL 323
            |...:....|.|  .|.....:|..|        |:..||.|........|..:.........:|
Human   213 HHGDHTGQTHGPPTPPTTPKTELQQA--------GAKPELKLEGRRPVDSGRQNIDFSNVDISEL 269

  Fly   324 QARLQ-AMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYGC--VKSEKSSPNAVVASAASP- 384
            .:.:. .|.|..::...:||||..| .||.|..:.|......|.  |.:.||:|:|    :|||
Human   270 SSEVMGTMDAFDVHEFDQYLPLGGP-APPEPGQAYGGAYFHAGASPVWAHKSAPSA----SASPT 329

  Fly   385 ------PNIIX--PTPLRFGAGTSSSAEH 405
                  |:|.   |:|..:|.....|.::
Human   330 ETGPPRPHIKTEQPSPGHYGDQPRGSPDY 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	43/70 (61%)
SOX8	NP_055402.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		16/50 (32%)
		Sox_N	18..89	CDD:315171	22/104 (21%)
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	58..100		7/64 (11%)
		SOX-TCF_HMG-box	101..171	CDD:238684	42/69 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..259		39/142 (27%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	224..298		18/82 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..378		13/45 (29%)
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	335..446		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740