DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox21a and tcf7l1a

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_571344.1	Gene:	tcf7l1a / 30523	ZFINID:	ZDB-GENE-980605-30	Length:	560	Species:	Danio rerio

Alignment Length:	454	Identity:	102/454 - (22%)
Similarity:	153/454 - (33%)	Gaps:	150/454 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISALLHRSHSH--------SNGYTSSGS-SNH---------------SHSSSLSPQLPGINLGLG 44
            :..:.|..|.|        ||.:.|.|: .:|               .|.|.|||..|   |..|
Zfish   161 VPVVQHPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDPKTGIPRTPHPSELSPYYP---LSPG 222

  Fly    45 MVGGL----------------------------GMGMSVGVGSGSGNTTPP---PMPPADL---A 75
            .||.:                            .:.|:..:.|...:...|   |.||..|   .
Zfish   223 AVGQIPHPLGWLVPQQGQHMYSIPPGGFRHPYPALAMNASMSSLVSSRFSPHMVPHPPHGLHQTG 287

  Fly    76 VP-PAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKM 139
            :| ||..:| |.|...:.....||.|..|    :...........|||:|:||||::.:..|.|:
Zfish   288 IPHPAIVSP-AIKQEPNGESPSNSTHGKP----SVPVKKEEEKKPHIKKPLNAFMLYMKEMRAKV 347

  Fly   140 AQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDY----KYRPRRKPKTLN 200
            ..:.....::.|::.||..|..|:..::..:.:.|::.|.||.:.:|.:    .|..|:|.|...
Zfish   348 VAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDC 412

  Fly   201 KSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHPH-QSP 264
            ||..|                                |..:..||  |..|.:|:|..... .||
Zfish   413 KSDSP--------------------------------SESNFSPQ--PKKQCVPYLSSEKMCDSP 443

  Fly   265 YQSHPHHPHPHPHHVQLAAATLSAKYGFGSPLELSLPRLPNAFPGLAHYPLDPTLALDLQAR--- 326
            ..||                        ||.|:  .|..|:|  .||. |..|......||:
Zfish   444 TSSH------------------------GSMLD--SPATPSA--ALAS-PAAPAATHSEQAQPLS 479

  Fly   327 LQAMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYGCVKSEKSSPNAVVASAASPPNIIXP 390
            |.....|..:|...:.||        |..|||:|..|...:.| .|.|   :...:.||:::.|
Zfish   480 LTTKPEGRAHHNHPHFPL--------PGKSSGSGSGSSMALHS-LSRP---IPFTSLPPSLLGP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	20/74 (27%)
tcf7l1a	NP_571344.1	CTNNB1_binding	1..233	CDD:285538	18/74 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..328		6/34 (18%)
		SOX-TCF_HMG-box	328..399	CDD:238684	20/70 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..513		41/188 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000