DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox21a and Sox10

DIOPT Version :9

Sequence 1:NP_001261827.1 Gene:Sox21a / 39567 FlyBaseID:FBgn0036411 Length:407 Species:Drosophila melanogaster
Sequence 2:NP_062066.1 Gene:Sox10 / 29361 RGDID:3735 Length:466 Species:Rattus norvegicus


Alignment Length:332 Identity:104/332 - (31%)
Similarity:138/332 - (41%) Gaps:107/332 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 SHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALH 181
            |..|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|..|||||:||:|||..|
  Rat   100 SKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQH 164

  Fly   182 MKEHPDYKYRPRRKPK---TLNKSPVPGGGGGGGGGGA-NGGVNAGGAGNSGP--SGPGSVGSPK 240
            .|:||||||:|||:..   ...::..|||....||..| .....:....:..|  ..|.|.|:|:
  Rat   165 KKDHPDYKYQPRRRKNGKAAQGEAECPGGETDQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPE 229

  Fly   241 DMQPQLSPLGQSLPHLHGHP-----HQSPYQS----------------HPH------------H- 271
                  .|.|||    ||.|     .::..||                .||            | 
  Rat   230 ------HPSGQS----HGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHE 284

  Fly   272 ------------------PHPHPHHVQLAAATLSAKYGFGSPLE--------LSLPRLPNAFPGL 310
                              |:.||.||...:|   |.||..|.|.        :|.|      ||:
  Rat   285 VMSNMETFDVTELDQYLPPNGHPGHVGSYSA---AGYGLSSALAVASGHSAWISKP------PGV 340

  Fly   311 AHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPP---SPPSSSGTGISS-----YGCV 367
            |...:.|. |:|.:|:::....|             |:.||   ..||:|....:|     ||..
  Rat   341 ALPTVSPP-AVDAKAQVKTETTG-------------PQGPPHYTDQPSTSQIAYTSLSLPHYGSA 391

  Fly   368 KSEKSSP 374
            ....|.|
  Rat   392 FPSISRP 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox21aNP_001261827.1 SOX-TCF_HMG-box 120..191 CDD:238684 44/70 (63%)
Sox10NP_062066.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67
Sox_N 12..93 CDD:289229
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693 62..102 1/1 (100%)
SOX-TCF_HMG-box 103..173 CDD:238684 43/69 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..198 16/37 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..275 16/71 (23%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693 228..310 16/91 (18%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693 353..466 13/59 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..375 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..466
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342385
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.740

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