DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and CFAP65

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_011509205.1	Gene:	CFAP65 / 255101	HGNCID:	25325	Length:	1941	Species:	Homo sapiens

Alignment Length:	323	Identity:	61/323 - (18%)
Similarity:	93/323 - (28%)	Gaps:	142/323 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 HHNAP-------TSHSNSNTGSHHNSHDHIKRPMNAFMVW-----SRG-------------QRRK 138
            ||..|       |.||:|...:       |.:|.:  :.|     :||             :.:|
Human   549 HHQDPLFLDLMGTCHSDSTKPA-------ILKPQH--LTWYRTHLARGLTLYPPDILDAMLKEKK 604

  Fly   139 MAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRK-------- 195
            :|||.                    .|.....|.:.:.:.|      |.|.|.|...
Human   605 LAQDQ--------------------NGALMIPIQDLEDMPA------PQYPYIPPMTEFFFDGTS 643

  Fly   196 -----PKTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGPGSV------------------- 236
                 |..::..||.              |:.|..  .||..|..|
Human   644 DITIFPPPISVEPVE--------------VDFGAC--PGPEAPNPVPLCLMNHTKGKIMVVWTRR 692

  Fly   237 -GSPKDMQPQ---LSPLGQSLPHLHGHPHQSPYQSHPHHPHPH-PHHVQLAAATLSAKYGFGSPL 296
             ..|..:.|:   :.||......||..|           |||: .:.|:|.|..:.......|.:
Human   693 SDCPFWVTPESCDVPPLKSMAMRLHFQP-----------PHPNCLYTVELEAFAIYKVLQSYSNI 746

  Fly   297 ELSLPRLPNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPP-SPPSSSG 358
            |             ....:.|:..|.::||..:.:||..:|    :|..|.:.|. .|..|||
Human   747 E-------------EDCTMCPSWCLTVRARGHSYFAGFEHH----IPQYSLDVPKLFPAVSSG 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	14/88 (16%)
CFAP65	XP_011509205.1	ASH	<159..>216	CDD:301105
CFAP65	XP_011509205.1	ASH	366..>432	CDD:301105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930