DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and Sry

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_036904.1	Gene:	Sry / 25221	RGDID:	3759	Length:	169	Species:	Rattus norvegicus

Alignment Length:	83	Identity:	53/83 - (63%)
Similarity:	67/83 - (80%)	Gaps:	0/83 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 HIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKE 184
            |:|||||||||||||:|||:||.||.|.||||||.||.:||.|||.:||||..||:||:.||.::
  Rat     4 HVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKHLGYQWKSLTEAEKRPFFQEAQRLKTLHREK 68

  Fly   185 HPDYKYRPRRKPKTLNKS 202
            :|:|||:|.|:.|...:|
  Rat    69 YPNYKYQPHRRVKVPQRS 86

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	48/70 (69%)
Sry	NP_036904.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250\|UniProtKB:Q05066	4..81		51/76 (67%)
		SOX-TCF_HMG-box	4..74	CDD:238684	47/69 (68%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	6..22		14/15 (93%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250\|UniProtKB:Q05066	52..84		16/31 (52%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q05066	75..81		2/5 (40%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000250\|UniProtKB:Q05738	92..144
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000250\|UniProtKB:Q05738	94..138
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..169
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840