DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and Sox9

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_035578.3	Gene:	Sox9 / 20682	MGIID:	98371	Length:	507	Species:	Mus musculus

Alignment Length:	499	Identity:	124/499 - (24%)
Similarity:	158/499 - (31%)	Gaps:	186/499 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSISALLHRSHSHSNGYTSSGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTT 65
            |..:...:..:.....|.:.:.|...|..|:.|| .|.                 |.||.:.||.
Mouse     1 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSP-CPS-----------------GSGSDTENTR 47

  Fly    66 PP----PMPPADL---------------AVPPA--------APTPVAPKMHQHTHHHGNSHHNAP 103
            |.    |....||               ||...        .|.||         ....|..|.|
Mouse    48 PQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPV---------RVNGSSKNKP 103

  Fly   104 TSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKR 168
                            |:||||||||||::..|||:|...|.:||:|:||.||..|:||.|.:||
Mouse   104 ----------------HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKR 152

  Fly   169 PFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGP 233
            ||::||:|||..|.|:||||||:|||:...                 .||...|..|.......|
Mouse   153 PFVEEAERLRVQHKKDHPDYKYQPRRRKSV-----------------KNGQAEAEEATEQTHISP 200

  Fly   234 GSVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPL-- 296
            .::..........|..|.|..|..|. |....|..|..|......||.....|..:   |.||
Mouse   201 NAIFKALQADSPHSSSGMSEVHSPGE-HSGQSQGPPTPPTTPKTDVQAGKVDLKRE---GRPLAE 261

  Fly   297 ---------------ELS------------------LPRLPNAFPGLAHYPLDPTLALDLQARLQ 328
                           |||                  ||  ||..||:.            ....|
Mouse   262 GGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLP--PNGHPGVP------------ATHGQ 312

  Fly   329 AMYAGSIY-------------HPWR----------YLPLISPETPPSPPS--------------- 355
            ..|.|| |             |.|.          ..|..:|:.|.:||.
Mouse   313 VTYTGS-YGISSTAPTPATAGHVWMSKQQAPPPPPQQPPQAPQAPQAPPQQQAPPQQPQAPQQQQ 376

  Fly   356 -------SSGTGISSYGCVKSEKSSPNAVVASAASPPNIIXPTP 392
                   ||..|.|....:|:|:.||:.........|..|..:|
Mouse   377 AHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQISYSP 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	43/70 (61%)
Sox9	NP_035578.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		17/83 (20%)
		Sox_N	22..94	CDD:315171	20/98 (20%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		7/48 (15%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		7/48 (15%)
		SOX-TCF_HMG-box	104..174	CDD:238684	42/69 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..271		34/131 (26%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..307		20/88 (23%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	275..284		3/8 (38%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..429		17/86 (20%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	392..507		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.700